Synthesis and biological evaluation of some 1,3,4-oxadiazole derivatives

被引：138
|
作者：
Manjunatha, K. [1 ]
Poojary, Boja [1 ]
Lobo, Prajwal L. [1 ]
Fernandes, Jennifer [2 ]
Kumari, N. Suchetha [3 ]
机构：
[1] Mangalore Univ, Dept Chem, Mangalagangothri 574199, Karnataka, India
[2] NGSM Coll Pharm, Dept Pharmachem, Derlakatte 574160, Karnataka, India
[3] KS Hegde Med Acad, Dept Biochem, Derlakatte 574162, Karnataka, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 11期
关键词：
1,3,4-Oxadiazol-2-thiones; Ibuprofen; 4-Methylthiophenyl; Antimicrobial activity; Anti-inflammatory activity; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ANTIMICROBIAL ACTIVITIES; CIPROFLOXACIN;
D O I：
10.1016/j.ejmech.2010.08.039
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The acid hydrazides (2) derived from ibuprofen and 4-methylthiophenyl acetic acids have been subjected to cyclization with carbon disulphide under basic conditions to yield 1,3,4-oxadiazol-2-thiones (3) which on aminomethylation with formaldehyde and secondary amines afforded a series of Mannich bases (4 and 5). Purity of the compounds has been confirmed by TLC. Structures of these compounds were established on the basis of elemental analyses and spectral studies. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic and antimicrobial activities. (C) 2010 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：5225 / 5233
页数：9
相关论文
共 50 条
  • [41] Synthesis, spectral analysis and biological evaluation of sulfamoyl and 1,3,4-oxadiazole derivatives of 3-pipecoline
    Aziz-ur-Rehman
    Aslam, Saira Jabeen
    Abbasi, Muhammad Athar
    Siddiqui, Sabahat Zahra
    Rasool, Shahid
    Shah, Syed Adnan Ali
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 32 (03) : 987 - 996
  • [42] Synthesis and evaluation of antimicrobial activity of novel 1,3,4-oxadiazole derivatives
    Mohite, P. B.
    Bhaskar, V. H.
    ORBITAL-THE ELECTRONIC JOURNAL OF CHEMISTRY, 2011, 3 (02): : 117 - 124
  • [43] Synthesis and evaluation of some novel substituted 1,3,4-oxadiazole and pyrazole derivatives for antitubercular activity
    Pattan, Shashikant R.
    Rabara, P. A.
    Pattan, Jayashri S.
    Bukitagar, A. A.
    Wakale, V. S.
    Musmade, D. S.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2009, 48 (10): : 1453 - 1456
  • [44] SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SOME 1,3,4-OXADIAZOLE INCORPORATED INDOLES
    Rajak, Harish
    Gupta, Arun Kumar
    Kharya, Murli Dhar
    Mishra, Pradeep
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 19 (01) : 29 - 32
  • [45] ANTIOXIDANT EVALUATION OF NEW 1,3,4-OXADIAZOLE DERIVATIVES
    Gatphoha, Banylla Felicity Dkhar
    Revanasiddappaa, B. C.
    HETEROCYCLIC LETTERS, 2021, 11 (01): : 39 - 44
  • [46] Synthesis, antibacterial and antitubercular evaluation of some 1,3,4-oxadiazole analogues
    Somani, Rakesh R.
    Shirodkar, P. Y.
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (08) : 6189 - 6194
  • [47] Synthesis and Properties of Novel 1,3,4-Oxadiazole Derivatives
    Zhang, Xiaobing
    Zhang, Zimin
    Zhang, Yugui
    Li, Min
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2009, 29 (02) : 297 - 301
  • [48] SYNTHESIS OF NEW ARYL DERIVATIVES OF 1,3,4-OXADIAZOLE
    GREKOV, AP
    AZEN, RS
    ZHURNAL OBSHCHEI KHIMII, 1961, 31 (02): : 407 - &
  • [49] Synthesis and Characterization of Mesogenic 1,3,4-Oxadiazole Derivatives
    Mahadeva, J.
    Umesha, K. B.
    Rai, K. M. L.
    Nagappa
    MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2009, 509 : 1016 - 1024
  • [50] Synthesis of some new 2,5-disubstituted 1,3,4-oxadiazole derivatives and their biological activity
    Khan, MSY
    Akhtar, M
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2003, 42 (04): : 900 - 904
12345