Objective To determine the diagnostic relevance of myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) in CSF of seronegative cases by retrospectively analyzing consecutive time-matched CSF of 80 MOG-Ab-seronegative patients with demyelinating disease. Methods The cohort included 44 patients with NMOSD and related disorders and 36 patients with multiple sclerosis (MS). Two independent neurologists blinded to diagnosis analyzed MOG-Abs by live cell-based immunofluorescence assay with goat anti-human immunoglobulin (Ig) G (whole molecule) antibody. Sera were tested at dilutions of 1:20 and 1:40, and a cutoff of 1:160 was considered for serum positivity. CSF specimens were tested undiluted and at 1:2 dilution with further titrations in case of positivity. Anti-IgG-Fc and anti-IgM-mu secondary antibodies were used to confirm the exclusive presence of MOG-IgG in positive cases. CSF of 13 MOG-Abs seropositive cases and 36 patients with neurodegenerative conditions was analyzed as controls. Results Three seronegative cases had CSF MOG-Abs (4% of the whole cohort or 7% of cases excluding patients with MS, in which MOG-Abs seem to lack diagnostic relevance). In particular, 2 patients with neuromyelitis optica spectrum disorder (NMOSD) and 1 with acute disseminated encephalomyelitis had MOG-Abs in CSF. Analysis with anti-IgG-Fc and anti-IgM confirmed the exclusive presence of MOG-IgG in the CSF of these patients. Among the control group, MOG-Abs were detectable in the CSF of 8 of 13 MOG-Ab-seropositive cases and in none of the patients with neurodegenerative disorders. Conclusion Although serum is the optimal specimen for MOG-Ab testing, analyzing CSF could improve diagnostic sensitivity in seronegative patients. This observation has relevant diagnostic impact and might provide novel insight into the biological mechanisms of MOG-Ab synthesis.
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Concord Repatriat Gen Hosp, Dept Neurol, Sydney, NSW, Australia
Univ Sydney, Brain & Mind Res Inst, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Reddel, Stephen W.
Henderson, Andrew
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Westmead Hosp, Dept Neurol, Sydney, NSW, Australia
Westmead Hosp, Dept Ophthalmol, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Henderson, Andrew
Parratt, John D. E.
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Univ Sydney, Royal North Shore Hosp, Cent Clin Sch, Dept Neurol, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Parratt, John D. E.
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Barnett, Michael
Gatt, Prudence N.
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Univ Sydney, Westmead Millennium Inst Med Res, Inst Immunol & Allergy Res, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Gatt, Prudence N.
Merheb, Vera
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Univ Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Merheb, Vera
Kumaran, Raani-Yogeeta Anusuiya
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Univ Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Kumaran, Raani-Yogeeta Anusuiya
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Pathmanandavel, Karrnan
Sinmaz, Nese
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Univ Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Sinmaz, Nese
Ghadiri, Mahtab
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Royal Prince Alfred Hosp, Dept Neurol, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Ghadiri, Mahtab
Yiannikas, Con
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Concord Repatriat Gen Hosp, Dept Neurol, Sydney, NSW, Australia
Univ Sydney, Royal North Shore Hosp, Cent Clin Sch, Dept Neurol, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Yiannikas, Con
Vucic, Steve
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Univ Sydney, Neurosci Res Australia, Western Clin Sch, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Vucic, Steve
Stewart, Graeme
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Univ Sydney, Westmead Millennium Inst Med Res, Inst Immunol & Allergy Res, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Stewart, Graeme
Bleasel, Andrew F.
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Westmead Hosp, Dept Neurol, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Bleasel, Andrew F.
Booth, David
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Univ Sydney, Westmead Millennium Inst Med Res, Inst Immunol & Allergy Res, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Booth, David
Fung, Victor S. C.
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Westmead Hosp, Dept Neurol, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Fung, Victor S. C.
Dale, Russell C.
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Univ Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia
Dale, Russell C.
Brilot, Fabienne
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Univ Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, AustraliaUniv Sydney, Childrens Hosp Westmead, Sydney Med Sch, Kids Res Inst,Inst Neurosci & Muscle Res,Neuroimm, Sydney, NSW, Australia