Therapeutic Strategies of Clustered Regularly Interspaced Palindromic Repeats-Cas Systems for Different Viral Infections

被引：4

作者：

Wahid, Braira ^{[1
]}

Usman, Sana ^{[1
]}

Ali, Amjad ^{[1
]}

Saleem, Komal ^{[1
]}

Rafique, Shazia ^{[2
]}

Naz, Zara

Ashfaq, Hafiz Ahsan ^{[1
]}

Idrees, Muhammad ^{[1
,3
]}

机构：

[1] Univ Punjab, Ctr Appl Mol Biol, 87 West Canal Bank Rd Thokar Niaz Baig, Lahore 5400, Pakistan

[2] Univ Punjab, Ctr Excellence Mol Biol, Lahore, Pakistan

[3] Vice Chancellor Hazara Univ, Mansehra, Pakistan

来源：

VIRAL IMMUNOLOGY | 2017年 / 30卷 / 08期

关键词：

CRISPR-Cas; HPV; HIV; HSV; HCV; HBV; JCV; antiviral defense; EPSTEIN-BARR-VIRUS; INHIBIT HIV-1 REPLICATION; HEPATITIS-B-VIRUS; CRISPR/CAS9; SYSTEM; GENOME; GENE; RNA; CRISPR-CAS9; MECHANISMS; EXPRESSION;

D O I：

10.1089/vim.2017.0055

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The clustered regularly interspaced palindromic repeats (CRISPR)/Cas systems have rapidly transitioned from intriguing prokaryotic defense systems to an efficient therapeutic tool. This cutting-edge technology is currently revolutionizing to combat hostile viruses because of its reproducibility, high potency, ease of use, limited off-target activity, and development of quick immune response against viruses. CRISPR gene editing technology eliminates the virus by breaking the DNA that ultimately halts viral replication. This review summarizes the advancements that have been made in the use of CRISPR-Cas technology in viral therapeutics.

引用

页码：552 / 559

页数：8

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