Vasoactive intestinal peptide (VIP) induces malignant transformation of the human prostate epithelial cell line RWPE-1

被引：36

作者：

Fernandez-Martinez, Ana B. ^{[1
]}

Bajo, Ana M. ^{[1
]}

Isabel Arenas, M. ^{[2
]}

Sanchez-Chapado, Manuel ^{[3
,4
]}

Prieto, Juan C. ^{[1
]}

Carmena, Maria J.

机构：

[1] Univ Alcala de Henares, Dept Biochem & Mol Biol, Alcala De Henares 28871, Spain

[2] Univ Alcala de Henares, Dept Cell Biol & Genet, Alcala De Henares 28871, Spain

[3] Univ Alcala de Henares, Dept Surg, Alcala De Henares 28871, Spain

[4] Principe Asturias Hosp, Dept Urol, Alcala De Henares 28871, Spain

来源：

CANCER LETTERS | 2010年 / 299卷 / 01期

关键词：

VIP; RWPE-1; cells; EMT; Tumorigenesis; Prostate cancer; PROTEIN-COUPLED RECEPTORS; MESENCHYMAL TRANSITION; NEUROENDOCRINE DIFFERENTIATION; ANTAGONISTIC ACTION; ANDROGEN RECEPTOR; HORMONE GHRH; CANCER CELLS; EXPRESSION; METASTASIS; APOPTOSIS;

D O I：

10.1016/j.canlet.2010.07.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The carcinogenic potential of vasoactive intestinal peptide (VIP) was analyzed in non-tumor human prostate epithelial cells (RWPE-1) and in vivo xenografts VIP induced morphological changes and a migratory phenotype consistent with stimulation of expression/activity of metalloproteinases MMP-2 and MMP 9 decreased E cadherin-mediated cell-cell adhesion and increased cell motility VIP increased cyclin D1 expression and cell proliferation that was blocked after VPAC(1)-receptor siRNA transfection Similar effects were seen in RWPE-1 tumors developed by subcutaneous injection of VIP-treated cells in athymic nude mice VIP acts as a cytokine in RWPE 1 cell transformation conceivably through epithelial-mesenchymal transition (EMT) reinforcing VIP role in prostate tumorigenesis (C) 2010 Elsevier Ireland Ltd All rights reserved

引用

页码：11 / 21

页数：11

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