Vasoactive intestinal peptide (VIP) induces malignant transformation of the human prostate epithelial cell line RWPE-1

被引：35
|
作者：
Fernandez-Martinez, Ana B. [1 ]
Bajo, Ana M. [1 ]
Isabel Arenas, M. [2 ]
Sanchez-Chapado, Manuel [3 ,4 ]
Prieto, Juan C. [1 ]
Carmena, Maria J.
机构：
[1] Univ Alcala de Henares, Dept Biochem & Mol Biol, Alcala De Henares 28871, Spain
[2] Univ Alcala de Henares, Dept Cell Biol & Genet, Alcala De Henares 28871, Spain
[3] Univ Alcala de Henares, Dept Surg, Alcala De Henares 28871, Spain
[4] Principe Asturias Hosp, Dept Urol, Alcala De Henares 28871, Spain
来源：
CANCER LETTERS | 2010年 / 299卷 / 01期
关键词：
VIP; RWPE-1; cells; EMT; Tumorigenesis; Prostate cancer; PROTEIN-COUPLED RECEPTORS; MESENCHYMAL TRANSITION; NEUROENDOCRINE DIFFERENTIATION; ANTAGONISTIC ACTION; ANDROGEN RECEPTOR; HORMONE GHRH; CANCER CELLS; EXPRESSION; METASTASIS; APOPTOSIS;
D O I：
10.1016/j.canlet.2010.07.019
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The carcinogenic potential of vasoactive intestinal peptide (VIP) was analyzed in non-tumor human prostate epithelial cells (RWPE-1) and in vivo xenografts VIP induced morphological changes and a migratory phenotype consistent with stimulation of expression/activity of metalloproteinases MMP-2 and MMP 9 decreased E cadherin-mediated cell-cell adhesion and increased cell motility VIP increased cyclin D1 expression and cell proliferation that was blocked after VPAC(1)-receptor siRNA transfection Similar effects were seen in RWPE-1 tumors developed by subcutaneous injection of VIP-treated cells in athymic nude mice VIP acts as a cytokine in RWPE 1 cell transformation conceivably through epithelial-mesenchymal transition (EMT) reinforcing VIP role in prostate tumorigenesis (C) 2010 Elsevier Ireland Ltd All rights reserved
引用
收藏
页码：11 / 21
页数：11
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