UNATTENDED LC/MS/MS METHOD DEVELOPMENT FOR DRUG DISCOVERY: APPLICATION FOR IN-VITRO METABOLIC STABILITY ASSAY

被引:0
|
作者
Gordon, W. Perry [1 ]
Mani, Tony [1 ]
Tuntland, Tove [1 ]
Richmond, Wendy [1 ]
机构
[1] Novartis Rsch Fndn Genom Inst, San Diego, CA USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
467
引用
收藏
页码:335 / 335
页数:1
相关论文
共 50 条
  • [31] LC-MS/MS method assay for simultaneous determination of the pretomanid and pyrazinamide in rat plasma by LC-MS/MS: Assessment of pharmacokinetic drug-drug interaction study
    Huang, Tao
    Wang, Li
    Wang, Fang
    Shen, Xin
    Wang, Libin
    ACTA CHROMATOGRAPHICA, 2024, 36 (01) : 7 - 13
  • [32] Immunopurification Reagents and Their Application in Biologics and Biomarker Quantitation Using LC-MS/MS in Drug Discovery
    Gautam, Shashyendra Singh
    Singh, Sheelendra Pratap
    JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2023, 61 (08) : 799 - 805
  • [33] Optimization,validation and application of an assay for the activity of HMG-CoA reductase in vitro by LC–MS/MS
    Jing Wang
    Ji-Ye Sun
    Chun-Jie Sha
    Yu-Feng Shao
    Yan-Hong Liu
    You-Xin Li
    Zhen-Wen Duan
    Wan-Hui Liu
    Journal of Pharmaceutical Analysis, 2015, 5 (06) : 383 - 388
  • [34] LC-MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate
    Amer, Sawsan M.
    Kadi, Adnan A.
    Darwish, Hany W.
    Attwa, Mohamed W.
    CHEMISTRY CENTRAL JOURNAL, 2017, 11
  • [35] An LC-MS/MS method for the determination of digitoxigenin in skin samples and its application to skin permeation and metabolic stability studies
    Feng, Xinchi
    Turley, Joel
    Xie, Zijian
    Pierre, Sandrine V.
    Koc, Hasan
    Khan, M. Omar
    Hao, Jinsong
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2017, 138 : 378 - 385
  • [36] A highly efficient and sensitive LC-MS/MS method for the determination of afatinib in human plasma: application to a metabolic stability study
    Kadi, Adnan A.
    Abdelhameed, Ali S.
    Darwish, Hany W.
    Attwa, Mohamed W.
    Al-Shakliah, Nasser S.
    BIOMEDICAL CHROMATOGRAPHY, 2016, 30 (08) : 1248 - 1255
  • [37] An Ultrafast UPLC-MS/MS Method for Characterizing the In Vitro Metabolic Stability of Acalabrutinib
    Attwa, Mohamed W.
    Bakheit, Ahmed H.
    Abdelhameed, Ali S.
    Kadi, Adnan A.
    MOLECULES, 2023, 28 (20):
  • [38] Correction to: Development of a simultaneous LC–MS/MS method to predict in vivo drug–drug interaction in mice
    Jung Jae Jo
    Jun Hyun Jo
    SunJoo Kim
    Jae-Mok Lee
    Sangkyu Lee
    Archives of Pharmacal Research, 2019, 42 : 380 - 380
  • [39] Development and validation of an LC-MS/MS generic assay platform for small molecule drug bioanalysis
    Parise, Robert A.
    Covey, Joseph M.
    Hollingshead, Melinda G.
    Srivastava, Apurva K.
    Synold, Timothy W.
    Beumer, Jan H.
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 203
  • [40] LC/MS applications in drug development
    Lee, MS
    Kerns, EH
    MASS SPECTROMETRY REVIEWS, 1999, 18 (3-4) : 187 - 279