Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

被引:115
|
作者
Rodriguez, Francisco [1 ]
Caruana, Pablo [1 ]
De la Fuente, Noa [2 ]
Espanol, Pia [3 ]
Gamez, Maria [4 ]
Balart, Josep [5 ]
Llurba, Elisa [3 ]
Rovira, Ramon [3 ]
Ruiz, Raul [1 ]
Martin-Lorente, Cristina [6 ]
Luis Corchero, Jose [7 ,8 ]
Virtudes Cespedes, Maria [1 ]
机构
[1] Hosp Santa Creu & Sant Pau, Grp Oncol Ginecol & Peritoneal, Inst Invest Biomed St Pau, Barcelona 08041, Spain
[2] Hosp HM Rosaleda, Serv Cirugia Gen & Aparato Digest, Santiago De Compostela 15701, Spain
[3] Univ Autonoma Barcelona, Dept Obstet & Gynecol, Hosp Santa Creu & St Pau, Barcelona 08041, Spain
[4] Hosp Santa Creu & Sant Pau, Dept Pharm, Barcelona 08041, Spain
[5] Hosp Santa Creu & Sant Pau, Dept Radiat Oncol, Barcelona 08041, Spain
[6] Hosp Santa Creu & Sant Pau, Dept Med Oncol, Barcelona 08041, Spain
[7] Univ Autonoma Barcelona, Inst Biotecnol & Biomed, Barcelona 08193, Spain
[8] Univ Autonoma Barcelona, CIBER BBN, Barcelona 08193, Spain
关键词
nanomedicine; cancer therapy; nanotechnology; approved nanopharmaceuticals; targeted therapy; PHASE-II TRIAL; ANTIBODY-DRUG CONJUGATE; METASTATIC BREAST-CANCER; ALBUMIN-BOUND PACLITAXEL; NAB-PACLITAXEL; STEM-CELLS; TUMOR MICROENVIRONMENT; DELIVERY SYSTEMS; RADIATION-THERAPY; 1ST-LINE THERAPY;
D O I
10.3390/biom12060784
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cancer is one of the main causes of death worldwide. To date, and despite the advances in conventional treatment options, therapy in cancer is still far from optimal due to the non-specific systemic biodistribution of antitumor agents. The inadequate drug concentrations at the tumor site led to an increased incidence of multiple drug resistance and the appearance of many severe undesirable side effects. Nanotechnology, through the development of nanoscale-based pharmaceuticals, has emerged to provide new and innovative drugs to overcome these limitations. In this review, we provide an overview of the approved nanomedicine for cancer treatment and the rationale behind their designs and applications. We also highlight the new approaches that are currently under investigation and the perspectives and challenges for nanopharmaceuticals, focusing on the tumor microenvironment and tumor disseminate cells as the most attractive and effective strategies for cancer treatments.
引用
收藏
页数:27
相关论文
共 50 条
  • [21] RNA-based Therapeutics: Past, Present and Future Prospects, Challenges in Cancer Treatment
    Goel, Anjana
    Rastogi, Amisha
    Jain, Mansi
    Niveriya, Kinjal
    CURRENT PHARMACEUTICAL BIOTECHNOLOGY, 2024, 25 (16) : 2125 - 2137
  • [22] Overcoming Treatment Challenges in Posterior Segment Diseases with Biodegradable Nano-Based Drug Delivery Systems
    Wu, Kevin Y.
    Joly-Chevrier, Maxine
    Akbar, Dania
    Tran, Simon D.
    PHARMACEUTICS, 2023, 15 (04)
  • [23] Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective
    Conceicao, Mariana
    Filippo, Leonardo Delello Di
    Duarte, Jonatas Lobato
    Beserra, Fernando Pereira
    Gremiao, Maria Palmira Daflon
    Chorilli, Marlus
    BRAIN BEHAVIOR & IMMUNITY-HEALTH, 2024, 42
  • [24] Nano-based approaches for diagnosis and therapy of gastric cancer
    Rai, Arya
    Rawat, Shristhi S.
    Chopra, Hitesh
    Singh, Inderbir
    Emran, Talha B.
    INTERNATIONAL JOURNAL OF SURGERY, 2023, 109 (07) : 2151 - 2152
  • [25] Nano-based apigenin delivery systems for cancer applications
    Cunha, Izi Vieira Nunes
    Campos, Angela Machado
    Caon, Thiago
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2024, 92
  • [26] A review of nano-based materials used as flocculants for water treatment
    Jumadi, J.
    Kamari, A.
    Hargreaves, J. S. J.
    Yusof, N.
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY, 2020, 17 (07) : 3571 - 3594
  • [27] A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy
    Weiwei Mu
    Qihui Chu
    Yongjun Liu
    Na Zhang
    Nano-Micro Letters, 2020, 12
  • [28] A review of nano-based materials used as flocculants for water treatment
    J. Jumadi
    A. Kamari
    J. S. J. Hargreaves
    N. Yusof
    International Journal of Environmental Science and Technology, 2020, 17 : 3571 - 3594
  • [29] A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy
    Mu, Weiwei
    Chu, Qihui
    Liu, Yongjun
    Zhang, Na
    NANO-MICRO LETTERS, 2020, 12 (01)
  • [30] The presence of pharmaceuticals in the environment due to human use - present knowledge and future challenges
    Kuemmerer, Klaus
    JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2009, 90 (08) : 2354 - 2366