Palladium-Catalyzed Alkene Carboalkoxylation Reactions of Phenols and Alcohols for the Synthesis of Carbocycles

被引：16
|
作者：
White, Derick R. [1 ]
Herman, Madeline I. [1 ]
Wolfe, John P. [1 ]
机构：
[1] Univ Michigan, Dept Chem, 930 North Univ Ave, Ann Arbor, MI 48109 USA
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 16期
关键词：
MITSUNOBU REACTION; CARBOAMINATION REACTIONS; ACTIVE CATALYST; ARYL ETHERS; ALKYL-ARYL; DIFUNCTIONALIZATION; AMINATION; OXIDATION;
D O I：
10.1021/acs.orglett.7b01975
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Intermolecular alkene difunctionalization reactions between terminal alkenes bearing a pendant aryl or alkenyl triflate electrophile and exogenous alcohol or phenol nucleophiles are described. These transformations afford substituted indanyl or alkylidenecyclopentyl ethers in high yield with excellent diastereoselectivity. The transformations proceed through intermolecular capture of an intermediate [pd(II)-alkene]+[OTf](-) complex by the alcohol or phenol nucleophile.
引用
收藏
页码：4311 / 4314
页数：4
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