Synthesis of Benzoylacetonitriles from Pd-Catalyzed Carbonylation of Aryl Iodides and Trimethylsilylacetonitrile

被引：29

作者：

Park, Ahbyeol ^{[1
]}

Lee, Sunwoo ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

DIRECT ALPHA-ARYLATION; COUPLING REACTIONS; BETA-KETONITRILES; CARBOXYLIC-ACIDS; VINYLIC HALIDES; CROSS-COUPLINGS; HECK REACTION; PALLADIUM; NITRILES; EFFICIENT;

D O I：

10.1021/ol300035u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile to produce benzoylacetonitrile derivatives through a one-pot, three-component reaction is described. This preparation method provides good yields of the carbonylated products without any additional ligands. It has a broad substrate scope with a high tolerance for a variety of functional groups.

引用

页码：1118 / 1121

页数：4

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