Synthesis of Benzoylacetonitriles from Pd-Catalyzed Carbonylation of Aryl Iodides and Trimethylsilylacetonitrile

被引：29
|
作者：
Park, Ahbyeol [1 ]
Lee, Sunwoo [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 04期
基金：
新加坡国家研究基金会;
关键词：
DIRECT ALPHA-ARYLATION; COUPLING REACTIONS; BETA-KETONITRILES; CARBOXYLIC-ACIDS; VINYLIC HALIDES; CROSS-COUPLINGS; HECK REACTION; PALLADIUM; NITRILES; EFFICIENT;
D O I：
10.1021/ol300035u
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Palladium-catalyzed carbonylation of aryl iodides and trimethylsilylacetonitrile to produce benzoylacetonitrile derivatives through a one-pot, three-component reaction is described. This preparation method provides good yields of the carbonylated products without any additional ligands. It has a broad substrate scope with a high tolerance for a variety of functional groups.
引用
收藏
页码：1118 / 1121
页数：4
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