Functional activity of mitochondria and generation of oxygen free radicals after prolonged myocardial ischemia: Effect of ischemic preconditioning

被引：0
|
作者：
Korkina, OV [1 ]
Khatkevich, AN [1 ]
Kapelko, VI [1 ]
Ruuge, EK [1 ]
机构：
[1] Russian Cardiol Sci Ind Complex, Expt Cardiol Res Inst, Moscow 121552, Russia
来源：
KARDIOLOGIYA | 2001年 / 41卷 / 06期
关键词：
ischemic preconditioning; rat heart; free radicals; mitochondria; spin traps;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Effect of ischemic preconditioning on the rate of oxygen free radicals formation, functional activity of mitochondria and restoration of cardiac contractility after prolonged ischemia was studied on isolated Langendorff-perfused rat hearts. Restoration of contractile function occurred in 50% of control hearts and in almost all hearts subjected to ischemic preconditioning (4 short cycles of ischemia and reperfusion). Mitochondria isolated from preconditioned hearts significantly better maintained their functional activity both after long-term ischemia and reperfusion. This was associated with significantly diminished rate of oxygen free radicals generation.
引用
收藏
页码：41 / 45
页数：5
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