RETRACTED: Regulation function of MMP-1 downregulated by siRNA on migration of heat-denatured dermal fibroblasts (Retracted Article)

被引：7
|
作者：
He, Xianghui [1 ]
Dai, Jinhua [2 ]
Fan, Youfen [1 ]
Zhang, Chun [1 ]
Zhao, Xihong [3 ]
机构：
[1] Ningbo 2 Hosp, Dept Burn, Ningbo, Zhejiang, Peoples R China
[2] Ningbo 2 Hosp, Dept Clin Lab, Ningbo, Zhejiang, Peoples R China
[3] Wuhan Inst Technol, Key Lab Green Chem Proc, Minist Educ, Sch Chem Engn & Pharm, 693,Xiongchu Ave, Wuhan 430073, Hubei, Peoples R China
来源：
BIOENGINEERED | 2017年 / 8卷 / 06期
关键词：
heat-denatured dermal fibroblast; MMP-1; migration; siRNA; TIMP; MATRIX METALLOPROTEINASES; EXPRESSION; PROLIFERATION; INHIBITION; MIR-29B;
D O I：
10.1080/21655979.2016.1267885
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cutaneous wound healing is a complex physiological process that requires the efforts of various cell types and signaling pathways and often results in thickened collagen-enriched healed tissue called a scar. Therefore, the identification of the mechanism of cutaneous wound healing is necessary and has great value in providing better treatment. Here, we demonstrated that MMP-1 inhibition could promote cell proliferation in dermal fibroblasts via the MTT assay. Meanwhile, we investigated cell migration by flow cytometry and tested type I collagenase activity. We found that MMP-1 inhibition promoted cell proliferation and inhibited cell migration and type I collagenase activity. In conclusion, our study demonstrated that MMP-1 might be a potential therapeutic target in cutaneous wound healing.
引用
收藏
页码：686 / 692
页数：7
相关论文
共 40 条
  • [31] RETRACTED: Silence of long non-coding RNA UCA1 inhibits hemangioma cells growth, migration and invasion by up-regulation of miR-200c (Retracted article. See vol. 298, 2022)
    Zhang, Jing
    Zhang, Chuanguang
    LIFE SCIENCES, 2019, 226 : 33 - 46
  • [32] RETRACTED: Effect of meso-dihydroguaiaretic acid from Machilus thunbergii Sieb et Zucc on NIMP-1 expression in heat shock-induced cultured primary human fibroblasts (Retracted article. See vol 21, pg 599, 2007)
    Moon, Hyungin
    Jung, Jae-Chul
    PHYTOTHERAPY RESEARCH, 2006, 20 (08) : 714 - 716
  • [33] RETRACTED: Kaempferol promotes proliferation, migration and differentiation of MC3T3-E1 cells via up-regulation of microRNA-101 (Retracted article. See vol. 49, pg. 157, 2021)
    Wang, Yang
    Chen, Hongyu
    Zhang, Hanyang
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2019, 47 (01) : 1050 - 1056
  • [34] RETRACTED: MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling (Retracted article. See vol. 43, 2023)
    Wu, Kun
    Zou, Jun
    Lin, Chao
    Jie, Zhi-Gang
    BIOSCIENCE REPORTS, 2019, 39
  • [35] RETRACTED ARTICLE: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors
    Aamir Ahmad
    Zhiwei Wang
    Dejuan Kong
    Shadan Ali
    Yiwei Li
    Sanjeev Banerjee
    Raza Ali
    Fazlul H. Sarkar
    Breast Cancer Research and Treatment, 2010, 122 : 337 - 346
  • [36] RETRACTED: FoxM1 down-regulation leads to inhibition of proliferation, migration and invasion of breast cancer cells through the modulation of extra-cellular matrix degrading factors (Retracted article. See vol. 158, pg. 607, 2016)
    Ahmad, Aamir
    Wang, Zhiwei
    Kong, Dejuan
    Ali, Shadan
    Li, Yiwei
    Banerjee, Sanjeev
    Ali, Raza
    Sarkar, Fazlul H.
    BREAST CANCER RESEARCH AND TREATMENT, 2010, 122 (02) : 337 - 346
  • [37] RETRACTED: Up-regulation of miRNA-148a inhibits proliferation, invasion, and migration while promoting apoptosis of cervical cancer cells by down-regulating RRS1 (Publication with Expression of Concern. See vol. 40, 2020) (Retracted Article)
    Zhang, Ying
    Sun, Bingmei
    Zhao, Lianbin
    Liu, Zhengling
    Xu, Zonglan
    Tian, Yonghui
    Hao, Changhong
    BIOSCIENCE REPORTS, 2019, 39
  • [38] RETRACTED: LINC01121 Inhibits Cell Apoptosis While Facilitating Proliferation, Migration, and Invasion Though Negative Regulation of the Camp/PKA Signaling Pathway via GLP1R (Retracted article. See vol. 55, pg. 385, 2021)
    Qian, Yi-Gang
    Ye, Zhou
    Chen, Hai-Yong
    Lv, Zhen
    Zhang, Ai-Bin
    Fan, Le
    Zhou, Jie
    Zheng, Shu-Sen
    Wang, Wei-lin
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2018, 47 (03) : 1007 - 1024
  • [39] RETRACTED: Long non-coding RNA LINC00968 reduces cell proliferation and migration and angiogenesis in breast cancer through up-regulation of PROX1 by reducing hsa-miR-423-5p (Retracted article. See JUL, 2022)
    Sun, Xianfu
    Huang, Tao
    Zhang, Chengjuan
    Zhang, Shengze
    Wang, Yingjie
    Zhang, Qiang
    Liu, Zhenzhen
    CELL CYCLE, 2019, 18 (16) : 1908 - 1924
  • [40] RETRACTED: Down-Regulation of Notch-1 and Jagged-1 Inhibits Prostate Cancer Cell Growth, Migration and Invasion, and Induces Apoptosis Via Inactivation of Akt, mTOR, and NF-κB Signaling Pathways (Retracted article. See vol. 117, pg. 1960, 2016)
    Wang, Zhiwei
    Li, Yiwei
    Banerjee, Sanjeev
    Kong, Dejuan
    Ahmad, Aamir
    Nogueira, Veronique
    Hay, Nissim
    Sarkar, Fazlul H.
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2010, 109 (04) : 726 - 736
1234