Role of Pharmacogenetics in the Treatment of Acute Myeloid Leukemia: Systematic Review and Future Perspectives

被引:7
|
作者
Pinto-Merino, Alvaro [1 ]
Labrador, Jorge [2 ,3 ,4 ]
Zubiaur, Pablo [5 ,6 ]
Alcaraz, Raquel [2 ]
Jose Herrero, Maria [7 ]
Montesinos, Pau [8 ]
Abad-Santos, Francisco [5 ,6 ]
Saiz-Rodriguez, Miriam [1 ,2 ]
机构
[1] Univ Burgos, Dept Hlth Sci, Burgos 09001, Spain
[2] Fdn Burgos Invest Salud FBIS, Hosp Univ Burgos, Res Unit, Burgos 09006, Spain
[3] Hosp Univ Burgos, Haematol Dept, Burgos 09006, Spain
[4] Univ Isabel I, Fac Ciencias Salud, Burgos 09003, Spain
[5] Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid 28029, Spain
[6] Univ Autonoma Madrid UAM, Clin Pharmacol Dept, Hosp Univ Princesa, Inst Invest Sanitaria Princesa IP, Madrid 28006, Spain
[7] Hosp Univ & Politecn La Fe, Pharmacogenet Dept, Valencia 46026, Spain
[8] Hosp Univ & Politecn La Fe, Haematol Dept, Valencia 46026, Spain
关键词
acute myeloid leukemia; pharmacogenetics; cytarabine; anthracyclines; FLT3; inhibitors; IDH inhibitors; CD33; hypomethylating agents; BCL2; SINGLE-NUCLEOTIDE POLYMORPHISMS; CYTIDINE DEAMINASE GENE; HAPMAP CELL-LINES; GEMTUZUMAB-OZOGAMICIN; ABCB1; POLYMORPHISMS; CLINICAL-OUTCOMES; INDUCED CARDIOTOXICITY; PROGNOSTIC OUTCOMES; FUNCTIONAL-ANALYSIS; TREATMENT RESPONSE;
D O I
10.3390/pharmaceutics14030559
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by remarkable toxicity and great variability in response to treatment. Plenteous pharmacogenetic studies have already been published for classical therapies, such as cytarabine or anthracyclines, but such studies remain scarce for newer drugs. There is evidence of the relevance of polymorphisms in response to treatment, although most studies have limitations in terms of cohort size or standardization of results. The different responses associated with genetic variability include both increased drug efficacy and toxicity and decreased response or resistance to treatment. A broad pharmacogenetic understanding may be useful in the design of dosing strategies and treatment guidelines. The aim of this study is to perform a review of the available publications and evidence related to the pharmacogenetics of AML, compiling those studies that may be useful in optimizing drug administration.
引用
收藏
页数:21
相关论文
共 50 条
  • [1] Systematic Review of Pharmacogenetics of ABC and SLC Transporter Genes in Acute Myeloid Leukemia
    Megias-Vericat, Juan Eduardo
    Martinez-Cuadron, David
    Solana-Altabella, Antonio
    Poveda, Jose Luis
    Montesinos, Pau
    [J]. PHARMACEUTICS, 2022, 14 (04)
  • [2] The role of cytokines in acute myeloid leukemia: A systematic review
    Kupsa, Tomas
    Horacek, Jan Milos
    Jebavy, Ladislav
    [J]. BIOMEDICAL PAPERS-OLOMOUC, 2012, 156 (04): : 291 - 301
  • [3] Management of Acute Myeloid Leukemia: Current Treatment Options and Future Perspectives
    Fleischmann, Maximilian
    Schnetzke, Ulf
    Hochhaus, Andreas
    Scholl, Sebastian
    [J]. CANCERS, 2021, 13 (22)
  • [4] Perspectives on the future of chronic myeloid leukemia treatment
    Appelbaum, FR
    [J]. SEMINARS IN HEMATOLOGY, 2001, 38 (03) : 35 - 42
  • [5] Acute Myeloid Leukemia Treatment in the Elderly: A Comprehensive Review of the Present and Future
    Choi, Jun H.
    Shukla, Mihir
    Abdul-Hay, Maher
    [J]. ACTA HAEMATOLOGICA, 2023, 146 (06) : 431 - 457
  • [6] Microtransplantation for Acute Myeloid Leukemia: A Systematic Review
    Pan, Bin
    Lazarus, Hillard M.
    Gale, Robert Peter
    [J]. JAMA ONCOLOGY, 2020, 6 (10) : 1614 - 1620
  • [7] Pharmacogenetics in the Treatment of Huntington's Disease: Review and Future Perspectives
    Garcia-Gonzalez, Xandra
    Cubo, Esther
    Simon-Vicente, Lucia
    Mariscal, Natividad
    Alcaraz, Raquel
    Aguado, Laura
    Rivadeneyra-Posadas, Jessica
    Sanz-Solas, Antonio
    Saiz-Rodriguez, Miriam
    [J]. JOURNAL OF PERSONALIZED MEDICINE, 2023, 13 (03):
  • [8] The role of adhesion molecules in acute myeloid leukemia and (hemato) oncology: A systematic review
    Kupsa, Tomas
    Horacek, Jan M.
    Jebavy, Ladislav
    [J]. BIOMEDICAL PAPERS-OLOMOUC, 2015, 159 (01): : 1 - 11
  • [9] Eficacy and mortality of venetoclax as promising treatment for acute myeloid leukemia: Systematic review
    Kosayuz, Sherina
    Tandokallo, Felicia
    Jhoputri, Caroline Friscila
    Atmaja, William Surya
    Kurniawan, Andree
    [J]. ANNALS OF ONCOLOGY, 2023, 34 : S1446 - S1447
  • [10] Dendritic cell vaccination strategy for the treatment of acute myeloid leukemia: a systematic review
    Khanmiri, Jamal Motallebzadeh
    Alizadeh, Mohsen
    Esmaeili, Sina
    Gholami, Zeinab
    Safarzadeh, Ali
    Khani-Eshratabadi, Mohammad
    Baghbanzadeh, Amir
    Alizadeh, Nazila
    Baradaran, Behzad
    [J]. CYTOTHERAPY, 2024, 26 (05) : 427 - 435