Glial Fibrillary Acidic Protein in Serum is Increased in Alzheimer's Disease and Correlates with Cognitive Impairment

被引：205

作者：

Oeckl, Patrick ^{[1
]}

Halbgebauer, Steffen ^{[1
]}

Anderl-Straub, Sarah ^{[1
]}

Steinacker, Petra ^{[1
]}

Huss, Andre M. ^{[1
]}

Neugebauer, Hermann ^{[1
]}

von Arnim, Christine A. F. ^{[1
]}

Diehl-Schmid, Janine ^{[2
]}

Grimmer, Timo ^{[2
]}

Kornhuber, Johannes ^{[3
,4
]}

Lewczuk, Piotr ^{[3
,4
,5
]}

Danek, Adrian ^{[6
]}

Ludolph, Albert C. ^{[1
]}

Otto, Markus ^{[1
]}

机构：

[1] Ulm Univ Hosp, Dept Neurol, Oberer Eselsberg 45, D-89081 Ulm, Germany

[2] Tech Univ Munich, Dept Psychiat & Psychotherapy, Klinikum Rechts Isar, Munich, Germany

[3] Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[4] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen, Germany

[5] Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland

[6] Ludwig Maximilians Univ Munchen, Dept Neurol, Univ Hosp, Munich, Germany

[7] Univ Ulm, German Consortium Frontotemporal Lobar Degenerat, Ulm, Germany

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2019年 / 67卷 / 02期

关键词：

Alzheimer's disease; astrocyte; biomarker; cerebrospinal fluid; differential diagnosis; frontotemporal dementia; GFAP; Lewy body dementia; Parkinson's disease; serum; NEUROFILAMENT LIGHT-CHAIN; CEREBROSPINAL-FLUID; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; PLASMA; DEMENTIA; RECOMMENDATIONS; CRITERIA; LEVEL;

D O I：

10.3233/JAD-180325

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Reliable blood biomarkers for Alzheimer's disease (AD) are missing. We measured astroglial GFAP in patients with AD (n = 28), frontotemporal dementia (bvFTD, n = 35), Parkinson's disease (n = 11), Lewy body dementias (n = 19), and controls (n = 34). Serum GFAP was increased in AD (p < 0.001) and DLB/PDD (p < 0.01), and cerebrospinal fluid GFAP was increased in all neurodegenerative diseases (p < 0.001). Serum GFAP correlated with the Mini-Mental State Examination score (r = -0.42, p < 0.001) and might be a follow-up marker in clinical trials. Sensitivity and specificity of serum GFAP for AD versus bvFTD was 89% and 79% and might be the first blood biomarker in the differential diagnosis of AD and bvFTD.

引用

页码：481 / 488

页数：8

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