Protease-activated receptor-1 (PAR-1): a promising molecular target for cancer

被引：38
|
作者：
Liu, Xuan [1 ,2 ,3 ]
Yu, Jiahui [3 ]
Song, Shangjin [3 ]
Yue, Xiaoqiang [3 ]
Li, Qi [1 ,2 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Med Oncol, Shanghai 201203, Peoples R China
[2] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Canc Inst, Shanghai 201203, Peoples R China
[3] Second Mil Med Univ, Changzheng Hosp, Dept Tradit Chinese Med, Shanghai 200003, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 63期
基金：
中国国家自然科学基金;
关键词：
PAR-1; cancer; carcinogenesis; invasion; metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; THROMBIN RECEPTOR; MATRIX METALLOPROTEINASE-1; PROSTATE-CANCER; TISSUE FACTOR; PROGENITOR CELLS; PROGNOSTIC VALUE; MELANOMA GROWTH; SIGNALING AXIS; FACTOR VIIA;
D O I：
10.18632/oncotarget.21015
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PAR-1 is expressed not only in epithelium, neurons, astrocytes, immune cells, but also in cancer-associated fibroblasts, ECs (epithelial cells), myocytes of blood vessels, mast cells, and macrophages in tumor microenvironment, whereas PAR-1 stimulates macrophages to synthesize and secrete thrombin as well as other growth factors, resulting in enhanced cell proliferation, tumor growth and metastasis. Therefore, considerable effort has been devoted to the development of inhibitors targeting PAR-1. Here, we provide a comprehensive review of PAR-1's role in cancer invasiveness and dissemination, as well as potential therapeutic strategies targeting PAR-1 signaling.
引用
收藏
页码：107334 / 107345
页数：12
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