Mannose-binding lectin gene (MBL-2) polymorphism in oral lichen planus

被引：4

作者：

Barkokebas, Andreza ^{[2
]}

Carvalho, Alessandra de Albuquerque T. ^{[1
]}

Eleuterio de Souza, Paulo Roberto ^{[3
]}

Gomez, Ricardo Santiago ^{[4
]}

Xavier, Guilherme Machado ^{[4
]}

Beder Ribeiro, Camila Maria ^{[1
]}

Crovella, Sergio ^{[5
]}

Porter, Stephen Ross ^{[6
]}

Leao, Jair Carneiro ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Clin & Odontol Prevent, BR-50670901 Recife, PE, Brazil

[2] Inst Med Integral Prof Fernando Figueira, Recife, PE, Brazil

[3] Univ Fed Rural Pernambuco, Dept Biol, Recife, PE, Brazil

[4] Univ Fed Minas Gerais, Dept Clin Patol & Cirurgia Odontol, Belo Horizonte, MG, Brazil

[5] Univ Fed Pernambuco, Lab Imunopatol Keiso Asami, Recife, PE, Brazil

[6] Eastman Dent Inst, Oral Med Unit, Div Maxillofacial Diagnost Surg & Med Sci, London, England

来源：

CLINICAL ORAL INVESTIGATIONS | 2011年 / 15卷 / 05期

关键词：

Oral lichen planus; Polymorphism; Mannose-binding lectin; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TUMOR-NECROSIS-FACTOR; RHEUMATOID-ARTHRITIS; INTERFERON-GAMMA; FACTOR-ALPHA; SUSCEPTIBILITY; DISEASE; INTERLEUKIN-1-BETA; ASSOCIATION; PROGRESSION;

D O I：

10.1007/s00784-010-0428-4

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

TNF-alpha may be associated with the etiopathogenesis of oral lichen planus (OLP), and it has been suggested that polymorphism of mannose-binding lectin (MBL) increases the in vitro production of TNF-alpha. The aim of the present study was to assess the relevance of genetic diversity of MBL in OLP. The study sample comprised 90 individuals, 45 OLP patients and 45 healthy volunteers. MBL-2 gene was amplified using real-time PCR. Frequency of A/A genotype was 55.6% in OLP and 53.3% in healthy volunteers. Likewise, A/0 heterozygote genotype was found in 42.2% and 35.6%; 2.2% and 11.1%, had the recessive 0/0 genotype respectively. Frequencies of the "A" and "0" alleles were 77% and 23% in the OLP group and 71.2% in control group. There were no statistically significant differences regarding genotype frequency (p=0.546) or allele frequency (p=0.497). In conclusion, no significant association was found between polymorphism of MBL-2 gene and OLP.

引用

页码：699 / 704

页数：6

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