Coumarins and alkaloids from the roots of Toddalia asiatica

被引：23
|
作者：
Sukieum, Sanwat [1 ,2 ]
Sang-aroon, Wichien [3 ]
Yenjai, Chavi [1 ,2 ]
机构：
[1] Khon Kaen Univ, Dept Chem, Fac Sci, Nat Prod Res Unit, Khon Kaen, Thailand
[2] Khon Kaen Univ, Ctr Excellence Innovat Chem, Khon Kaen, Thailand
[3] Rajamangala Univ Technol Isan, Dept Chem, Fac Engn, Khon Kaen, Thailand
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 08期
关键词：
Toddalia asiatica; 2R-Acetoxytoddanol; quinolone alkaloid; phenanthridine; CONSTITUENTS; AMIDES; ACULEATA;
D O I：
10.1080/14786419.2017.1374264
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The EtOAc and MeOH extracts of the roots of Toddalia asiatica Lam. were investigated for the roots' chemical constituents. Two new compounds including 2R-acetoxytoddanol (1) and 8S-10-O-demethylbocconoline (3) as well as 15 known compounds were isolated. Compound 10 showed strong cytotoxicity against KB cells with an IC50 value of 2.60g/mL, which is nearly equal to the ellipticine standard, but showed no activity against Vero cells. Alkaloid 3 displayed weak cytotoxicity against the KB cell line with an IC50 value of 21.69g/mL. [GRAPHICS] .
引用
收藏
页码：944 / 952
页数：9
相关论文
共 50 条
  • [31] TODDALIDIMERINE, A DIMERIC BENZOPHENANTHRIDINE ALKALOID FROM TODDALIA-ASIATICA
    SHARMA, PN
    SHOEB, A
    KAPIL, RS
    POPLI, SP
    [J]. PHYTOCHEMISTRY, 1981, 20 (12) : 2781 - 2783
  • [32] The tumor specific cytotoxicity of dihydronitidine from Toddalia asiatica Lam
    Iwasaki, H
    Oku, H
    Takara, R
    Miyahira, H
    Hanashiro, K
    Yoshida, Y
    Kamada, Y
    Toyokawa, T
    Takara, K
    Inafuku, M
    [J]. CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2006, 58 (04) : 451 - 459
  • [33] The first total synthesis of toddaquinoline, an alkaloid from Toddalia asiatica
    Harrowven, DC
    Nunn, MIT
    Blumire, NJ
    Fenwick, DR
    [J]. TETRAHEDRON, 2001, 57 (20) : 4447 - 4454
  • [34] TODDASIN, A NEW DIMERIC COUMARIN FROM TODDALIA-ASIATICA
    SHARMA, PN
    SHOEB, A
    KAPIL, RS
    POPLI, SP
    [J]. PHYTOCHEMISTRY, 1980, 19 (06) : 1258 - 1260
  • [35] The tumor specific cytotoxicity of dihydronitidine from Toddalia asiatica Lam
    Hironori Iwasaki
    Hirosuke Oku
    Ryo Takara
    Hanako Miyahira
    Kaoru Hanashiro
    Yasuhiko Yoshida
    Yasuhiro Kamada
    Tetsuya Toyokawa
    Kensaku Takara
    Masashi Inafuku
    [J]. Cancer Chemotherapy and Pharmacology, 2006, 58 : 451 - 459
  • [36] Compounds from Toddalia asiatica: Immunosuppressant Activity and Absolute Configurations
    Reinhardt, Jakob K.
    Zimmermann-Klemd, Amy M.
    Danton, Ombeline
    Smiesko, Martin
    Gruendemann, Carsten
    Hamburger, Matthias
    [J]. JOURNAL OF NATURAL PRODUCTS, 2020, 83 (10): : 3012 - 3020
  • [37] Anti-platelet aggregation constituents from formosan Toddalia asiatica
    Tsai, IL
    Wun, MF
    Teng, CM
    Ishikawa, T
    Chen, IS
    [J]. PHYTOCHEMISTRY, 1998, 48 (08) : 1377 - 1382
  • [38] CHEMICAL-CONSTITUENTS OF TODDALIA-ASIATICA
    SHARMA, PN
    SHOEB, A
    KAPIL, RS
    POPLI, SP
    [J]. INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1981, 20 (10): : 936 - 937
  • [39] ALKALOIDS OF TODDALIA ACULEATA PERS
    GOVINDACHARI, TR
    VISWANATHAN, N
    [J]. INDIAN JOURNAL OF CHEMISTRY, 1967, 5 (06): : 280 - +
  • [40] Coumarins and acridone alkaloids with α-glucosidase inhibitory and antioxidant activity from the roots of Paramignya trimera
    Trinh, Duong H.
    Tran, Phuong T.
    Trinh, Binh T. D.
    Nguyen, Hieu T.
    Nguyen, Hiep D.
    Ha, Ly D.
    Nguyen, Lien-Hoa D.
    [J]. PHYTOCHEMISTRY LETTERS, 2020, 35 : 94 - 98
12345