Coumarins and alkaloids from the roots of Toddalia asiatica

被引：23
|
作者：
Sukieum, Sanwat [1 ,2 ]
Sang-aroon, Wichien [3 ]
Yenjai, Chavi [1 ,2 ]
机构：
[1] Khon Kaen Univ, Dept Chem, Fac Sci, Nat Prod Res Unit, Khon Kaen, Thailand
[2] Khon Kaen Univ, Ctr Excellence Innovat Chem, Khon Kaen, Thailand
[3] Rajamangala Univ Technol Isan, Dept Chem, Fac Engn, Khon Kaen, Thailand
来源：
NATURAL PRODUCT RESEARCH | 2018年 / 32卷 / 08期
关键词：
Toddalia asiatica; 2R-Acetoxytoddanol; quinolone alkaloid; phenanthridine; CONSTITUENTS; AMIDES; ACULEATA;
D O I：
10.1080/14786419.2017.1374264
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The EtOAc and MeOH extracts of the roots of Toddalia asiatica Lam. were investigated for the roots' chemical constituents. Two new compounds including 2R-acetoxytoddanol (1) and 8S-10-O-demethylbocconoline (3) as well as 15 known compounds were isolated. Compound 10 showed strong cytotoxicity against KB cells with an IC50 value of 2.60g/mL, which is nearly equal to the ellipticine standard, but showed no activity against Vero cells. Alkaloid 3 displayed weak cytotoxicity against the KB cell line with an IC50 value of 21.69g/mL. [GRAPHICS] .
引用
收藏
页码：944 / 952
页数：9
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