Au-Catalyzed Piperidine Synthesis via Tandem Acyloxy Migration/Intramolecular [3+2] Cycloaddition of Enynyl Esters

被引：30
|
作者：
Zheng, Huaiji [1 ]
Huo, Xing [1 ]
Zhao, Changgui [1 ]
Jing, Peng [1 ]
Yang, Juan [1 ]
Fang, Bowen [1 ]
She, Xuegong [1 ,2 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Gansu, Peoples R China
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 24期
关键词：
GOLD CATALYSIS; EFFICIENT SYNTHESIS; CYCLOISOMERIZATION; PLATINUM; BOND; REARRANGEMENTS; CYCLIZATION; N-ENYNES; ACTIVATION;
D O I：
10.1021/ol202746s
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An Au-catalyzed tandem protocol involving enynyl ester isomerization and subsequent intramolecular [3 + 2] cyclization has been developed. This strategy provides an efficient approach for the synthesis of polyfunctional piperidines, which are subunits of many bioactive molecules.
引用
收藏
页码：6448 / 6451
页数：4
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