The Continuous-Flow Synthesis of Styrenes Using Ethylene in a Palladium-Catalysed Heck Cross-Coupling Reaction

被引：58
|
作者：
Bourne, Samuel L. [1 ]
Koos, Peter [1 ]
O'Brien, Matthew [1 ]
Martin, Benjamin [2 ]
Schenkel, Berthold [2 ]
Baxendale, Ian R. [1 ]
Ley, Steven V. [1 ]
机构：
[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England
[2] Novartis Pharma AG, Chem & Analyt Dev, CH-4057 Basel, Switzerland
来源：
SYNLETT | 2011年 / 18期
基金：
英国工程与自然科学研究理事会;
关键词：
vinylation; membrane; flow; ethylene; styrene; ORGANIC-SYNTHESIS; MICROREACTOR; CHEMISTRY; ARYL; ARYLATION; ECONOMY; HALIDES;
D O I：
10.1055/s-0031-1289291
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report a palladium-catalysed ethylene Heck reaction for the vinylation of aryl iodides using a tube-in-tube gas-liquid reactor. The flow process afforded various styrenes in short reaction times, employing moderate ethylene pressure.
引用
收藏
页码：2643 / 2647
页数：5
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