The synthesis of substituted pyridylpyrimidine fungicides using palladium-catalysed cross-coupling reactions

被引：64
|
作者：
Hargreaves, SL [1 ]
Pilkington, BL [1 ]
Russell, SE [1 ]
Worthington, PA [1 ]
机构：
[1] Zeneca Agrochem, Dept Chem, Jealotts Hill Res Stn, Bracknell RG42 6ET, Berks, England
来源：
TETRAHEDRON LETTERS | 2000年 / 41卷 / 10期
关键词：
coupling reactions; palladium catalysts; pyridines; pyrimidines; fungicides;
D O I：
10.1016/S0040-4039(00)00007-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various substituted phenyl, pyridyl and benzyl zinc chlorides have been generated from the corresponding lithium or magnesium organometallic reagents. These have been cross-coupled with 2-(6-bromo-2-pyridyl)pyrimidines in the presence of tetrakis(triphenylphosphine)palladium(0) to produce a series of substituted pyridylpyrimidine fungicides in 32-99% yields. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1653 / 1656
页数：4
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