Visible-Light-Promoted C2 Selective Arylation of Quinoline and Pyridine N-Oxides with Diaryliodonium Tetrafluoroborate

被引：37

作者：

Li, Dazhi ^{[1
]}

Liang, Ce ^{[2
]}

Jiang, Zaixing ^{[2
]}

Zhang, Junzheng ^{[2
]}

Zhuo, Wang-Tao ^{[2
]}

Zou, Fan-Yue ^{[2
]}

Wang, Wan-Peng ^{[2
]}

Gao, Guo-Lin ^{[2
]}

Song, Jinzhu ^{[1
]}

机构：

[1] Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150001, Heilongjiang, Peoples R China

[2] Harbin Inst Technol, Sch Chem & Chem Engn, MIIT Key Lab Crit Mat Technol New Energy Convers, Harbin 150001, Heilongjiang, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2020年 / 85卷 / 04期

关键词：

CROSS-COUPLING REACTIONS; ONE-POT SYNTHESIS; H ARYLATION; PALLADIUM COMPLEXES; ARYL; HETEROARYL; SALTS; HETEROCYCLES; PHOSPHINE; REDUCTION;

D O I：

10.1021/acs.joc.9b02933

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A protocol of visible-light-promoted C2 selective arylation of quinoline and pyridine N-oxides, with diaryliodonium tetrafluoroborate as an arylation reagent, using eosin Y as a photocatalyst for the construction of N-heterobiaryls was presented. This methodology provided an efficient way for the synthesis of 2-aryl-substituted quinoline and pyridine N-oxides. This strategy has the following advantages: specific regioselectivity, simple operation, good functional group tolerance, and high to moderate yields under mild conditions.

引用

页码：2733 / 2742

页数：10

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