Tumor growth-promoting properties of macrophage migration inhibitory factor (MIF)

被引：134
|
作者：
Mitchell, RA [1 ]
Bucala, R [1 ]
机构：
[1] Picower Inst Med Res, Manhasset, NY 11030 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2000年 / 10卷 / 05期
关键词：
angiogenesis; MAP kinases; macrophage migration inhibitory factor; MIF; proliferation;
D O I：
10.1006/scbi.2000.0328
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
First identified nt al nearly 40 years ago, macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine and is an essential component of immune and inflammatory responses. Recent studies suggest that MIF may also contribute to multiple aspects of tumor progression and neoplasia. This review will attempt to summarize these findings focusing on MIF's ability to modulate cell proliferation, tumor. angiogenesis and tumor suppressor activity.
引用
收藏
页码：359 / 366
页数：8
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