A Multiscale TiO2 Nanorod Array for Ultrasensitive Capture of Circulating Tumor Cells

被引：59

作者：

Sun, Na ^{[1
]}

Li, Xinpan ^{[1
,2
]}

Wang, Zhili ^{[1
]}

Zhang, Ruihua ^{[1
,2
]}

Wang, Jine ^{[1
]}

Wang, Kewei ^{[1
]}

Pei, Renjun ^{[1
]}

机构：

[1] Univ Chinese Acad Sci, Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Key Lab Nanobio Interface, Suzhou 215123, Peoples R China

[2] Xi An Jiao Tong Univ, Sch Pharm, Sch Mat Sci & Engn, State Key Lab Mech Behav Mat, Xian 710049, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2016年 / 8卷 / 20期

基金：

中国国家自然科学基金;

关键词：

multiscale; TiO2 nanorod array; circulating tumor cells; high efficient capture; EFFICIENT CAPTURE; PERIPHERAL-BLOOD; BREAST-CANCER; SUBSTRATE; BIOINTERFACES; INTERFACES; PARTICLES; SURFACES; CULTURE; FUTURE;

D O I：

10.1021/acsami.6b02178

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

In this work, a uniform multiscale TiO2 nanorod array is fabricated to provide a "multi -scale interacting platform" for cell capture, which exhibits excellent capture specificity and sensitivity of the target cells after modification with bovine serum albumin (BSA) and DNA aptamer. After studying the capture performance of the BSA-aptamer TiO2 nanorod substrates and other nanostructured substrates, we can conclude that the multisacle TiO2 nanorod substrates could indeed effectively enhance the capture yields of target cancer cells. The capture yield of artificial blood samples on

引用

页码：12638 / 12643

页数：6

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