Synthesis and Anxiolytic Activity of Some Novel 5-oxo-1, 4-oxazepine Derivatives

被引：0
|
作者：
AbdelFattah, Bothiana A. [2 ]
Khalifa, Maha M. A. [1 ]
El-Sehrawi, Hend [1 ]
Fayed, Eman [1 ]
Bayoumi, Ashraf [3 ]
Said, Makarem [2 ]
机构：
[1] Al Azhar Univ Girls, Fac Pharm, Dept Pharmaceut Chem, Cairo 11754, Egypt
[2] Cairo Univ, Fac Pharm, Dept Organ Chem, Cairo, Egypt
[3] Al Azhar Univ Boys, Fac Pharm, Dept Organ Chem, Cairo, Egypt
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2011年 / 8卷 / 04期
关键词：
Synthesis; 5-Oxo-1; 4-Oxazepine derivatives; Open field test; Anxiolytic activity; OXAZEPINE DERIVATIVES; RATS; BEHAVIOR; AMOXAPINE; AGENTS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A novel synthetic procedure for a series of 4-Aryl-3-phenyl-6,7,8,9-tetrahydro-benzothieno[3,2-f][1,4]oxazepin-5(4H)-one 8a-s derivatives had been described. Six compounds 8a,b,h,j,m,s were selected and submitted to pharmacological evaluation for anxiolytic activity in the open field test. All the test compounds except 8b significantly reduced the exploratory activity and the emotionality of the rats in the open-field. These inhibitory results are in agreement with the effect of reference standard chlorpromazine as a tranquillizer and anxiolytic in the same conditions.
引用
收藏
页码：330 / 338
页数：9
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