Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus

被引：14
|
作者：
Sukhov, I. B. [1 ]
Lebedeva, M. F. [1 ]
Zakharova, I. O. [1 ]
Derkach, K. V. [1 ]
Bayunova, L. V. [1 ]
Zorina, I. I. [1 ]
Avrova, N. F. [1 ]
Shpakov, A. O. [1 ]
机构：
[1] Russian Acad Sci, Lab Mol Endocrinol & Neurochem, IM Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 168卷 / 03期
关键词：
type 2 diabetes mellitus; spatial memory; gangliosides; intranasal administration; GM1; GANGLIOSIDE; COGNITIVE-DEVELOPMENT; BRAIN; CELLS;
D O I：
10.1007/s10517-020-04699-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We analyzed the effects of intranasal administration of insulin (0.48 U/rat) and gangliosides (6 mg/kg) on spatial memory in rats with the neonatal model of the type 2 diabetes mellitus. The development of diabetes was verified by the glucose tolerance test. Insulin and gangliosides improved training and reversal training in diabetic rats in a modified version of Morris water maze test and reduced the time of finding the hidden platform. High effectiveness of intranasal administration of gangliosides to animals for the normalization of cognitive functions was shown for the first time. The effects of insulin and gangliosides were similar during training, but during reversal training, gangliosides were more effective. At the same time, intranasally administered insulin, unlike gangliosides, partially normalized glucose tolerance in rats with type 2 diabetes mellitus.
引用
收藏
页码：317 / 320
页数：4
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