Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus

被引：14

作者：

Sukhov, I. B. ^{[1
]}

Lebedeva, M. F. ^{[1
]}

Zakharova, I. O. ^{[1
]}

Derkach, K. V. ^{[1
]}

Bayunova, L. V. ^{[1
]}

Zorina, I. I. ^{[1
]}

Avrova, N. F. ^{[1
]}

Shpakov, A. O. ^{[1
]}

机构：

[1] Russian Acad Sci, Lab Mol Endocrinol & Neurochem, IM Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 168卷 / 03期

关键词：

type 2 diabetes mellitus; spatial memory; gangliosides; intranasal administration; GM1; GANGLIOSIDE; COGNITIVE-DEVELOPMENT; BRAIN; CELLS;

D O I：

10.1007/s10517-020-04699-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We analyzed the effects of intranasal administration of insulin (0.48 U/rat) and gangliosides (6 mg/kg) on spatial memory in rats with the neonatal model of the type 2 diabetes mellitus. The development of diabetes was verified by the glucose tolerance test. Insulin and gangliosides improved training and reversal training in diabetic rats in a modified version of Morris water maze test and reduced the time of finding the hidden platform. High effectiveness of intranasal administration of gangliosides to animals for the normalization of cognitive functions was shown for the first time. The effects of insulin and gangliosides were similar during training, but during reversal training, gangliosides were more effective. At the same time, intranasally administered insulin, unlike gangliosides, partially normalized glucose tolerance in rats with type 2 diabetes mellitus.

引用

页码：317 / 320

页数：4

共 50 条

[1] Intranasal Administration of Insulin and Gangliosides Improves Spatial Memory in Rats with Neonatal Type 2 Diabetes Mellitus
I. B. Sukhov
M. F. Lebedeva
I. O. Zakharova
K. V. Derkach
L. V. Bayunova
I. I. Zorina
N. F. Avrova
A. O. Shpakov
[J]. Bulletin of Experimental Biology and Medicine, 2020, 168 : 317 - 320
[2] Intranasal Administration of Insulin Eliminates the Deficit of Long-Term Spatial Memory in Rats with Neonatal Diabetes Mellitus
Chistyakova, O. V.
Bondareva, V. M.
Shipilov, V. N.
Sukhov, I. B.
Shpakov, A. O.
[J]. DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2011, 440 (01) : 216 - 218
[3] Intranasal administration of insulin eliminates the deficit of long-term spatial memory in rats with neonatal diabetes mellitus
O. V. Chistyakova
V. M. Bondareva
V. N. Shipilov
I. B. Sukhov
A. O. Shpakov
[J]. Doklady Biochemistry and Biophysics, 2011, 440 : 216 - 218
[4] Long-term intranasal insulin administration improves spatial memory in male rats with prolonged type 1 diabetes mellitus and in healthy rats
Sukhov I.B.
Shipilov V.N.
Chistyakova O.V.
Trost A.M.
Shpakov A.O.
[J]. Doklady Biological Sciences, 2013, 453 (1) : 349 - 352
[5] Intranasal Insulin and Gangliosides Correct Cognitive Impairments and Signaling Pathways in the Hippocampus of Rats with Type 2 Diabetes Mellitus
I. O. Zakharova
L. V. Bayunova
K. V. Derkach
A. O. Shpakov
N. F. Avrova
[J]. Journal of Evolutionary Biochemistry and Physiology, 2023, 59 : 1935 - 1953
[6] Intranasal Insulin and Gangliosides Correct Cognitive Impairments and Signaling Pathways in the Hippocampus of Rats with Type 2 Diabetes Mellitus
Zakharova, I. O.
Bayunova, L. V.
Derkach, K. V.
Shpakov, A. O.
Avrova, N. F.
[J]. JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2023, 59 (06) : 1935 - 1953
[7] Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus
Cortez-Navarrete, Marisol
Martinez-Abundis, Esperanza
Perez-Rubio, Karina G.
Gonzalez-Ortiz, Manuel
Mendez-del Villar, Miriam
[J]. JOURNAL OF MEDICINAL FOOD, 2018, 21 (07) : 672 - 677
[8] Functional state of hypothalamic signaling systems in rats with type 2 diabetes mellitus treated with intranasal insulin
I. B. Sukhov
K. V. Derkach
O. V. Chistyakova
V. M. Bondareva
A. O. Shpakov
[J]. Journal of Evolutionary Biochemistry and Physiology, 2016, 52 : 204 - 216
[9] Functional state of hypothalamic signaling systems in rats with type 2 diabetes mellitus treated with intranasal insulin
Sukhov, I. B.
Derkach, K. V.
Chistyakova, O. V.
Bondareva, V. M.
Shpakov, A. O.
[J]. JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY, 2016, 52 (03) : 204 - 216
[10] Effects of Intranasally Administered Insulin and Gangliosides on Metabolic Parameters and Activity of the Hepatic Insulin System in Rats with Type 2 Diabetes Mellitus
I. O. Zakharova
L. V. Bayunova
K. V. Derkach
I. O. Ilyasov
A. O. Shpakov
N. F. Avrova
[J]. Journal of Evolutionary Biochemistry and Physiology, 2022, 58 : 380 - 394

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