Artificial metallonucleases

被引：412
|
作者：
Mancin, F
Scrimin, P
Tecilla, P
Tonellato, U
机构：
[1] Univ Padua, Dipartimento Sci Chim, I-35131 Padua, Italy
[2] Univ Padua, Ist CNR Tecnol Membrane, Sez Padova, I-35131 Padua, Italy
[3] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 20期
关键词：
D O I：
10.1039/b418164f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.
引用
收藏
页码：2540 / 2548
页数：9
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