Artificial metallonucleases

被引：412
|
作者：
Mancin, F
Scrimin, P
Tecilla, P
Tonellato, U
机构：
[1] Univ Padua, Dipartimento Sci Chim, I-35131 Padua, Italy
[2] Univ Padua, Ist CNR Tecnol Membrane, Sez Padova, I-35131 Padua, Italy
[3] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 20期
关键词：
D O I：
10.1039/b418164f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The development of synthetic agents able to hydrolytically cleave DNA with high efficiency and selectivity is a fascinating challenge that will show the way to obtaining artificial nucleases able to compete with the natural enzymes. This Feature Article highlights the progress reported toward the realization of synthetic nucleases with particular attention to the strategies that can be pursued to improve efficiency and sequence selectivity.
引用
收藏
页码：2540 / 2548
页数：9
相关论文
共 50 条
  • [1] Progress in artificial metallonucleases
    Mancin, Fabrizio
    Scrimin, Paolo
    Tecilla, Paolo
    CHEMICAL COMMUNICATIONS, 2012, 48 (45) : 5545 - 5559
  • [2] METALLONUCLEASES - REAL AND ARTIFICIAL
    BASILE, LA
    BARTON, JK
    METAL IONS IN BIOLOGICAL SYSTEMS, 1989, 25 : 31 - 103
  • [3] Design of artificial metallonucleases with oxidative mechanism
    Jiang, Qin
    Xiao, Nan
    Shi, Pengfei
    Zhu, Yangguang
    Guo, Zijian
    COORDINATION CHEMISTRY REVIEWS, 2007, 251 (15-16) : 1951 - 1972
  • [4] Development of site-specific artificial metallonucleases
    Mareze, Vania Aparecida
    Terenzi, Hernan
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2017, 22 : S127 - S127
  • [5] Resin-supported catalytic dendrimers as multivalent artificial metallonucleases
    Zaupa, Giovanni
    Prins, Leonard J.
    Scrimin, Paolo
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (14) : 3816 - 3820
  • [6] Studies on NCoIE7-a potential platform for artificial metallonucleases
    Gyurcsik, B.
    Czene, A.
    Toth, E.
    Nemeth, E.
    Otten, H.
    Poulsen, J. N.
    Larsen, S.
    Christensen, H. M.
    Nagata, K.
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 : S82 - S82
  • [7] Acetyl pyridine-based palladium(II) compounds as an artificial metallonucleases
    Thakor, Khyati P.
    Lunagariya, Miral V.
    Patel, Mohan N.
    JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2017, 35 (13): : 2925 - 2937
  • [8] Towards artificial metallonucleases for gene therapy: recent advances and new perspectives
    Gyurcsik, Bela
    Czene, Aniko
    FUTURE MEDICINAL CHEMISTRY, 2011, 3 (15) : 1935 - 1966
  • [9] Target-activated metal complex (TaMC) as a new strategy for artificial metallonucleases
    Anam, Swapnil
    Todd, Matthew
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 242
  • [10] Synthesis, spectral investigation and development of tetrahedral copper(II) complexes as artificial metallonucleases and antimalarial agents
    Mehta, Jugal V.
    Gajera, Sanjay B.
    Patel, Disha D.
    Patel, Mohan N.
    APPLIED ORGANOMETALLIC CHEMISTRY, 2015, 29 (06) : 357 - 367
12345