DNA polymerase ι of mammals as a participant in translesion synthesis of DNA

被引：6
|
作者：
Gening, L. V. [1 ]
机构：
[1] Russian Acad Sci, Inst Mol Genet, Moscow 123182, Russia
来源：
BIOCHEMISTRY-MOSCOW | 2011年 / 76卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
DNA translesion synthesis; error-prone DNA polymerase; DNA polymerase iota; PIGMENTOSUM VARIANT CELLS; POL-IOTA; PYRIMIDINE DIMERS; REPLICATION; ETA; BYPASS; MOUSE; MICE; FIDELITY; PHOTOPRODUCTS;
D O I：
10.1134/S0006297911010081
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review describes the properties of some specialized DNA polymerases participating in translesion synthesis of DNA. Special attention is given to these properties in vivo. DNA polymerase iota (Pol iota) of mammals has very unusual features and is extremely error-prone. Based on available data, a hypothesis is proposed explaining how mammalian cells can explore the unusual features of DNA Pol iota to bypass DNA damages and to simultaneously prevent its mutagenic potential.
引用
收藏
页码：61 / 68
页数：8
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