Genomic Croesus: Experimental evolutionary genetics of Drosophila aging

被引:4
|
作者
Rose, Michael R. [1 ]
Burke, Molly K. [1 ]
机构
[1] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92697 USA
基金
加拿大自然科学与工程研究理事会;
关键词
Aging; Population genomics; Experimental evolution; Drosophila; QTL; QUANTITATIVE TRAIT LOCI; BRISTLE NUMBER VARIATION; AFFECTING LIFE-SPAN; NATURAL-SELECTION; AFFECTING LONGEVITY; MELANOGASTER; SENESCENCE; GENES; AGE; POLYMORPHISMS;
D O I
10.1016/j.exger.2010.08.025
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
For more than 40 years, multiple laboratories have studied Drosophila stocks that have been forced to evolve slowed rates of aging and increased average longevities. These stocks have been used to test both physiological and genetic theories of aging, yielding a number of interesting findings. A little-noticed problem is that these tests have too frequently produced positive results with respect to physiological and genetic mechanisms underlying slowed aging. A genomic interpretation of this copious success is that hundreds of genetic loci have undergone changes in allele frequency or gene expression as a result of selection for slowed aging. This implicates many genetic mechanisms in the control of aging, in general, across the diversity of aging species. As the technology for surveying genomes and transcriptomes continues to improve rapidly, the loci of aging are becoming ever easier to identify. But interpreting the detailed functional consequences of all of these loci presents a radically larger challenge. Like Croesus, experimental gerontology is faced with the problem of genomic foundations for aging which are extremely rich. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:397 / 403
页数:7
相关论文
共 50 条
  • [1] Genetics of aging in Drosophila
    Rose, MR
    EXPERIMENTAL GERONTOLOGY, 1999, 34 (05) : 577 - 585
  • [2] Evolutionary genetics of aging
    Kirkwood, TBL
    ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE, 1999, 32 (02): : 9 - 9
  • [3] Evolutionary Genetics of Drosophila Mediopunctata
    Louis Bernard Klaczko
    Genetica, 2006, 126 : 43 - 55
  • [4] EVOLUTIONARY GENETICS OF DROSOPHILA ESTERASES
    OAKESHOTT, JG
    VANPAPENRECHT, EA
    BOYCE, TM
    RUSSELL, RJ
    HEALY, MJ
    GENETICA, 1993, 90 (2-3) : 239 - 268
  • [5] Evolutionary genetics of Drosophila mediopunctata
    Klaczko, LB
    GENETICA, 2006, 126 (1-2) : 43 - 55
  • [6] Evolutionary behavioral genetics in Drosophila
    Peixoto, AA
    ADVANCES IN GENETICS, VOL 47, 2002, 47 : 117 - 150
  • [7] Evolutionary genetics of aging in Daphnia
    Yampolsky, LY
    Galimov, YR
    ZHURNAL OBSHCHEI BIOLOGII, 2005, 66 (05): : 416 - 424
  • [8] EVOLUTIONARY POPULATION GENETICS OF DROSOPHILA ANANASSAE
    Yukilevich, Roman
    QUARTERLY REVIEW OF BIOLOGY, 2017, 92 (03): : 334 - 335
  • [9] Evolutionary genetics:: the Drosophila model -: Preface
    Joshi, A
    JOURNAL OF GENETICS, 2003, 82 (03) : 77 - 78
  • [10] Evolutionary Quantitative Genetics of Genomic Imprinting
    O'Brien, Eleanor K.
    Wolf, Jason B.
    GENETICS, 2019, 211 (01) : 75 - 88