Genetic Variation in IL28B: Impact on Drug Development for Chronic Hepatitis C Infection

被引：8

作者：

Clark, P. J. ^{[1
,2
]}

Thompson, A. J. V. ^{[1
,2
]}

McHutchison, J. G. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Div Gastroenterol, Durham, NC USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2010年 / 88卷 / 05期

基金：

英国医学研究理事会;

关键词：

INTERFERON-LAMBDA; PEGINTERFERON ALPHA-2A; PLUS RIBAVIRIN; TELAPREVIR; GENOTYPE-1; INHIBITOR; THERAPY; TYPE-1;

D O I：

10.1038/clpt.2010.185

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

As more pharmacogenomic insights into diseases and their treatments and toxicities are published each year, the challenge arises to incorporate such insights into clinical practice and drug development.(1) For instance, recent genomic discoveries related to hepatitis C offer a challenge to clinicians, researchers, and health administrators to translate this information into knowledge in order to develop safer and more effective therapeutic strategies for all patients.

引用

页码：708 / 711

页数：4

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