Synthesis, characterization and antibacterial activity of fumaric acid incorporated silver nanoparticle hydrogel

Nano compounds find extensive application in many fields and in medicine, they are used widely in drug delivery system. Of late, attention is paid to their use as possible antimicrobial agents. In this study, fumaric acid (FA) has been considered for the synthesis of nano compound by incorporating it with silver nano particles (AgNps) embedded in agar-agar matrix. The nano material hydrogel so formed (FA-AgNps) has been characterized by FTIR, UV-Vis and TEM that revealed the presence of characteristic bands and absorbance maxima as well as the shapes of AgNps and FA-AgNps hydrogel. When tested against five human pathogens Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Proteus mirabilis, the synthesized nanoparticle hydrogel has shown significant effect against four bacteria and no activity against one strain when compared to FA, AgNps and standard drugs in the concentrations studied.