In vivo terahertz spectroscopy of pigmentary skin nevi: Pilot study of non-invasive early diagnosis of dysplasia

被引：116
|
作者：
Zaytsev, Kirill I. [1 ]
Kudrin, Konstantin G. [2 ,3 ]
Karasik, Valeriy E. [1 ]
Reshetov, Igor V. [2 ,3 ]
Yurchenko, Stanislav O. [1 ]
机构：
[1] Bauman Moscow State Tech Univ, Moscow 105005, Russia
[2] PA Hertzen Moscow Res Inst Oncol, Moscow 125284, Russia
[3] Fed Medicobiol Agcy Russia, Inst Improvement Profess Skill, Moscow 125371, Russia
来源：
APPLIED PHYSICS LETTERS | 2015年 / 106卷 / 05期
基金：
俄罗斯科学基金会;
关键词：
TIME-DOMAIN SPECTROSCOPY; BASAL-CELL CARCINOMA; EX-VIVO; GENERATION; MELANOMA; CANCER; THZ;
D O I：
10.1063/1.4907350
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
In vivo terahertz (THz) spectroscopy of pigmentary skin nevi is performed. The in vivo THz dielectric characteristics of healthy skin and dysplastic and non-dysplastic skin nevi are reconstructed and analyzed. The dielectric permittivity curves of these samples in the THz range exhibit significant differences that could allow non-invasive early diagnosis of dysplastic nevi, which are melanoma precursors. An approach for differentiating dysplastic and non-dysplastic skin nevi using the THz dielectric permittivity is proposed. The results demonstrate that THz pulsed spectroscopy is potentially an effective tool for non-invasive early diagnosis of dysplastic nevi and melanomas of the skin. (C) 2015 AIP Publishing LLC.
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页数：5
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