Effect of decabrominated diphenyl ether exposure on spatial learning and memory, the expression and phosphorylation of hippocampal glutamate receptor subunits in adult Sprague-Dawley rats

被引：7
|
作者：
Li Xiong [1 ]
Hao Liyue [1 ]
Zeng Fancai [2 ]
Li Maoting [1 ]
Li Ya [1 ]
He Ting [1 ]
Yang Zhen [1 ]
Zhu Shanshan [1 ]
Gu Wenwen [1 ]
Tang Yan [1 ]
机构：
[1] Southwest Med Univ, Sch Publ Hlth, 1,Sect 1,Xianglin Rd, Longmatan Dist 646000, Luzhou, Peoples R China
[2] Southwest Med Univ, Dept Biochem & Mol Biol, 1,Sect 1,Xianglin Rd, Longmatan Dist 646000, Luzhou, Peoples R China
来源：
JOURNAL OF TOXICOLOGICAL SCIENCES | 2018年 / 43卷 / 10-12期
关键词：
Decabrominated diphenyl ethers; Learning and memory; Hippocampi; Glutamate receptor; Phosphorylation; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; NEONATAL EXPOSURE; NR2B SUBUNIT; KINASE-II; OCCUPATIONAL-EXPOSURE; SPONTANEOUS BEHAVIOR; PBDES; MICE; RESTORATION;
D O I：
10.2131/jts.43.645
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Previous studies have reported the potential developmental neurobehavioral effects of decabrominated diphenyl ethers (BDE 209) on developing animals, but the effects on adult animals are rare or controversial and the mechanism is not fully understood. In the present study, male adult Sprague-Dawley rats performed poor spatial learning and memory in Morris water maze after exposure to BDE 209 by gavage for 30 days. The expression of hippocampal glutamate receptor subunits NR1, NR2B and GIuR1, the phosphorylation of NR2B subunit at Ser1301 (p-NR2B Ser1303) and GluR1 subunit at Ser831 (p-GluR1 Ser831) were all decreased, and the phosphorylation ratio of NR2B revealed an increasing trend after BDE 209 exposure. The present study provided evidence that BDE 209 could induce spatial learning and memory deficits in adult rats, and further explored the potential mechanism.
引用
收藏
页码：645 / 657
页数：13
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