Dual function of Ras in Raf activation

被引：0
|
作者：
Li, W [1 ]
Melnick, M [1 ]
Perrimon, N [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Genet, Howard Hughes Med Inst, Boston, MA 02115 USA
来源：
DEVELOPMENT | 1998年 / 125卷 / 24期
关键词：
Ras; Raf; receptor tyrosine kinase; Drosophila melanogaster;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The small guanine nucleotide binding protein p21(Ras) plays an important role in the activation of the Raf kinase. However, the precise mechanism by which Raf is activated remains unclear. It has been proposed that the sole function of p21(Ras) in Raf activation is to recruit Raf to the plasma membrane. We have used Drosophila embryos to examine the mechanism of Raf (Draf) activation in the complete absence of p21(Ras) (Ras1). We demonstrate that the role of Ras1, in Draf activation is not limited to the translocation of Draf to the membrane through a Ras1-Draf association. In addition, Rasl is essential for the activation of an additional factor which in turn activates Draf.
引用
收藏
页码：4999 / 5008
页数：10
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