Structural characterization and protective effect against murine sepsis of fucogalactans from Agaricus bisporus and Lactarius rufus

被引：42
|
作者：
Ruthes, Andrea C. [1 ]
Rattmann, Yanna D. [1 ]
Carbonero, Elaine R. [2 ]
Gorin, Philip A. J. [1 ]
Iacomini, Marcello [1 ]
机构：
[1] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil
[2] Univ Fed Goias, Dept Quim, BR-75704020 Catalao, Go, Brazil
来源：
CARBOHYDRATE POLYMERS | 2012年 / 87卷 / 02期
关键词：
Edible mushrooms; Agaricus bisporus; Lactarius rufus; Fucogalactans; Sepsis; IMMUNOMODULATOR PGG-GLUCAN; CECAL LIGATION; MUSHROOMS; MODEL; INFLAMMATION; ELUCIDATION; BODIES; FUNGI; ORGAN; GUT;
D O I：
10.1016/j.carbpol.2011.09.071
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Fucogalactans from edible Agaricus bisporus (RFP-Ab) and wild Lactarius rufus (RFP-Lr) mushrooms were obtained on aqueous extraction followed by purification. RFP-Ab had M-w 43.8 x 10(4) g mol(-1) and RFP-Lr M-w 1.4 x 10(4) g mol(-1). RFP-Lr had a (1 -> 6)-linked alpha-D-Galp main-chain partially substituted at O-2 by nonreducing end-units of alpha-L-Fucp (29%). While RFP-Ab had a similar main chain, it was partially substituted at O-2 by nonreducing end-units of alpha-L-Fucp (2.8%) and beta-D-Galp (14.5%), and partially methylated at HO-3. Both RFP-Lr and RFP-Ab were tested in mice against polymicrobial sepsis. Lethality rate, myeloperoxidase (MPO) activity and cytokine levels were determined. It was observed a reduction in late mortality rate by 62.5% and 50%, respectively, prevention of neutrophil accumulation in ileum and decreasing in TNF-alpha and IL-1 beta serum levels. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1620 / 1627
页数：8
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