New 5-modified 2′-deoxyuridine derivatives: synthesis and antituberculosis activity

被引：6
|
作者：
Shmalenyuk, E. R. [1 ]
Karpenko, I. L. [1 ]
Chernousova, L. N. [2 ]
Chizhov, A. O. [3 ]
Smirnova, T. G. [2 ]
Andreevskaya, S. N. [2 ]
Alexandrova, L. A. [1 ]
机构：
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
[2] Russian Acad Med Sci, Cent TB Res Inst, Moscow 107564, Russia
[3] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2014年 / 63卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
nucleosides; 2 '-deoxyuridine; synthesis; inhibitor; antimycobacterial activity; tuberculosis; Mycobacterium tuberculosis; TUBERCULOSIS; C5;
D O I：
10.1007/s11172-014-0572-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New 2'-deoxyuridine derivatives containing long-chain hydrophilic substituents or hydrophilic groups at the 5 position of uracil were synthesized. 5-[4-(2-Carboxyethylcarbonylamino)-butyloxymethyl]-2'-deoxyuridine completely inhibits the growth of Mycobacterium tuberculosis at a concentration of 50 mu g mL(-1). However, oligo(ethylene glycol) derivatives do not exhibit activity even at high concentrations.
引用
收藏
页码：1197 / 1200
页数：4
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