Axonal flip-flops and oscillators

被引:32
|
作者
Baker, MD [1 ]
机构
[1] UCL, Dept Biol, London WC1E 6BT, England
关键词
D O I
10.1016/S0166-2236(00)01645-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The strange and unpleasant sensations (paraesthesiae) or asynchronous motor-unit activation (fasciculation) that result from a period of limb ischaemia are examples of ectopic discharge in peripheral nerves. Ectopic activity also results from demyelination and is associated with serious neurological conditions, such as multiple sclerosis. A build-up of extracellular K+ in the internode and persistent Na+ currents are now implicated in generating the different forms of activity arising in normal and demyelinated axons.
引用
收藏
页码:514 / 519
页数:6
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