Solid-Phase Synthesis of Lysobactin (Katanosin B): Insights into Structure and Function

被引：10

作者：

Hall, Edward A. ^{[1
]}

Kuru, Erkin ^{[1
]}

VanNieuwenhze, Michael S. ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 11期

基金：

美国国家卫生研究院;

关键词：

COUPLING REAGENT; REMARKABLE RESISTANCE; DEPBT;

D O I：

10.1021/ol300926d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The solid phase synthesis of the cyclic depsipeptide antibiotic lysobactin is described. The natural product was synthesized via a linear approach using mostly an Fmoc-strategy solid phase peptide synthesis (SPPS) with a single purification. A lysobactin analog has also been synthesized displaying nanomolar membrane disruption activity not seen with the natural product.

引用

页码：2730 / 2733

页数：4

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