Src-family protein tyrosine kinase negatively regulates cerebellar long-term depression

被引:9
|
作者
Tsuruno, Shun [1 ,2 ]
Kawaguchi, Shin-ya [1 ,2 ]
Hirano, Tomoo [1 ,2 ]
机构
[1] Kyoto Univ, Grad Sch Sci, Dept Biophys, Kyoto 6068502, Japan
[2] Japan Sci & Technology Corp, CREST, Kawaguchi, Saitama 3320012, Japan
关键词
Purkinje neuron; cerebellum; synaptic plasticity; LTD; Src-family protein tyrosine kinase; mGluR1;
D O I
10.1016/j.neures.2008.03.004
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Protein phosphorylation is a major mechanism for the regulation of synaptic transmission. Previous studies have shown that several serine/threonine kinases are involved in the induction of long-term depression (LTD) at excitatory synapses on a Purkinje neuron (PN) in the cerebellum. Here, we show that Src-family protein tyrosine kinases (SFKs) are involved in the regulation of the LTD induction. Intracellular application of c-Src suppressed LTD. We also show that application of a SFK-selective inhibitor PP2 recovered LTD from the suppression caused by the inhibition of mGluR1 activity. These results indicate that SFKs negatively regulate the LTD induction at excitatory synapses on a cerebellar PN. (c) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All fights reserved.
引用
收藏
页码:329 / 332
页数:4
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