Gentamicin ototoxicity induced apoptosis of the vestibular hair cells of guinea pigs

被引：58
|
作者：
Nakagawa, T [1 ]
Yamane, H [1 ]
Shibata, S [1 ]
Nakai, Y [1 ]
机构：
[1] OSAKA CITY UNIV, SCH MED, DEPT OTORHINOLARYNGOL, OSAKA 545, JAPAN
来源：
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 1997年 / 254卷 / 01期
关键词：
labyrinthine vestibule; gentamicin-induced apoptosis; nick-end labelling; hair cell changes;
D O I：
10.1007/BF02630749
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
To clarify mechanisms of inner ear cell death induced by aminoglycosides, we used an in situ nick-end labelling method to examine guinea pig vestibular epithelia after chronic systemic treatments with gentamicin to produce apoptosis. Such changes occurred in damaged hair cells, suggesting that this process may be crucial for subsequent repair and cell regeneration.
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收藏
页码：9 / 14
页数：6
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