No reduction of HCV viral load in HIV patients co-infected with HCV genotype 1 during a 30 days course of nitazoxanide monotherapy

被引：4

作者：

Laufer, N. ^{[1
,2
,3
]}

Abusamra, L. ^{[2
,4
]}

Bolcic, F. ^{[3
]}

Gun, A. ^{[4
]}

Rolon, M. J. ^{[2
]}

Perez, H. ^{[2
]}

Krolewiecki, A. ^{[4
]}

Salomon, H. ^{[3
]}

Quarleri, J. ^{[3
]}

Cahn, P. ^{[2
,4
]}

机构：

[1] Univ Buenos Aires, Fac Med, CONICET, Ctr Nacl Referencia SIDA,Dept Microbiol, Buenos Aires, DF, Argentina

[2] Hosp Fernandez, Div Enfermedades Infecciosas, Buenos Aires, DF, Argentina

[3] Consejo Nacl Invest Cient & Tecn CONICET, Buenos Aires, DF, Argentina

[4] Fdn Huesped, Buenos Aires, DF, Argentina

来源：

ANTIVIRAL RESEARCH | 2011年 / 92卷 / 03期

关键词：

Nitazoxanide; HCV genotype 1; HIV/HCV co-infection; HCV treatment; CHRONIC HEPATITIS-C; RANDOMIZED CONTROLLED-TRIAL; ZAMBIAN CHILDREN; VIRUS; CRYPTOSPORIDIOSIS; PEGINTERFERON; TIZOXANIDE; INHIBITORS; RIBAVIRIN; THERAPY;

D O I：

10.1016/j.antiviral.2011.10.006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There are two new drugs approved and several in development for treatment of chronic HCV; among them nitazoxanide (NTZ). Twelve HIV/HCV genotype 1 co-infected patients were enrolled prospectively to receive a 30 days course of oral NTZ 500 mg bid. This therapy was well tolerated in this group of HIV patients co-infected with HCV genotype 1. Nevertheless no changes in HCV viral load were observed during treatment in none of the patients evaluated. This data suggests that despite the promising results reported for HCV genotype 4 mono-infected patients, NTZ exhibit poor activity as monotherapy in HIV/HCV co-infected patients with genotype 1. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：497 / 499

页数：3

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