Enantioselective Total Synthesis of (+)-Scuteflorin A Using Organocatalytic Asymmetric Epoxidation

被引：21

作者：

Bartlett, Christopher J. ^{[1
]}

Day, David P. ^{[1
]}

Chan, Yohan ^{[1
]}

Allin, Steven M. ^{[2
]}

McKenzie, Michael J. ^{[3
]}

Slawin, Alexandra M. Z. ^{[4
]}

Page, Philip C. Bulman ^{[1
]}

机构：

[1] Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England

[2] Univ Keele, Sch Phys & Geog Sci, Keele ST5 5BG, Staffs, England

[3] Charnwood Mol Ltd, Loughborough LE11 5GA, Leics, England

[4] Univ St Andrews, Sch Chem, Mol Struct Lab, St Andrews KY16 9ST, Fife, Scotland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2012年 / 77卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

IMINIUM SALTS; SCUTELLARIA-LATERIFLORA; ANGELICA-DECURSIVA; CANCER CELLS; STEREOSTRUCTURES; (+)-DECURSINOL; CATALYSTS; COUMARIN;

D O I：

10.1021/jo2021407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We report the first enantioselective total synthesis of (+)-scuteflorin A in 14% overall yield, employing a chiral iminium salt to effect an organocatalytic asymmetric epoxidation of xanthyletin in >99% ee as the key step.

引用

页码：772 / 774

页数：3

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