Concise Synthesis of (1 R,2 S,3 R,6 R )-6-Ethoxy-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, a Key Intermediate for the Synthesis of Uvacalols I and J

被引：1

作者：

Surender, Banothu ^{[1
]}

Vinaykumar, Allam ^{[1
]}

Bharathkumar, Hanumantharayappa ^{[1
]}

Rao, Batchu Venkateswara ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Organ Synth & Proc Chem Dept, Uppal Rd, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNLETT | 2022年 / 33卷 / 06期

关键词：

uvacalols; carbasugars; methyl glucopyranoside; asymmetric synthesis; RING CLOSING METATHESIS; POLYOXYGENATED CYCLOHEXENES; STEREOSELECTIVE-SYNTHESIS; STRUCTURAL VALIDATION; METABOLITES;

D O I：

10.1055/s-0041-1737965

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Uvacalols are novel carbasugars isolated from the genera Uvaria. In this study, we report concise syntheses of (1R,2S,3R,6R)-6- ethoxy-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, a key intermediate for the synthesis of uvacalols I and J, and of its epimer (1R,2S,3S,6R)- 6-ethoxy-4-(hydroxymethyl)cyclohex-4-ene-1,2,3-triol, starting from cheap and readily available methyl D-glucopyranoside. © 2022 Georg Thieme Verlag. All rights reserved.

引用

页码：551 / 554

页数：4

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