6, 9-Disubstituted purines as potent dual Src/Abl tyrosine kinase inhibitors targeting the "inactive" conformation

被引：0

作者：

Huang, Wei-Sheng ^{[1
]}

Zhu, Xiaotian ^{[1
]}

Wang, Yihan ^{[1
]}

Azam, Mohammad ^{[2
]}

Wen, David ^{[1
]}

Sundaramoorthi, Raji ^{[1
]}

Thomas, R. Mathew ^{[1
]}

Liu, Shuangying ^{[1
]}

Banda, Geeta ^{[1
]}

Lentini, Scott ^{[1
]}

Das, Sasmita ^{[1
]}

Xu, Qihong ^{[1
]}

Keats, Jeff ^{[1
]}

Wang, Frank ^{[1
]}

Wardwell, Scott ^{[1
]}

Ning, Yaoyu ^{[1
]}

Snodgrass, Joseph T. ^{[1
]}

Broudy, Mark I. ^{[1
]}

Russian, Karin ^{[1
]}

Iuliucci, John ^{[1
]}

Dalgarno, David C. ^{[1
]}

Clackson, Timothy P. ^{[1
]}

Daley, George Q. ^{[2
]}

Sawyer, Tomi K. ^{[1
]}

Shakespeare, William C. ^{[1
]}

机构：

[1] ARIAD Pharmaceut Inc, Cambridge, MA 02139 USA

[2] Harvard Univ, Dept Biol Chem & Mol Pharmacol, Dana Farber Canc Inst,Childrens Hosp,Med Sch, Div Hematol Oncol,Brigham & Womens Hosp, Boston, MA 02115 USA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 237卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

168-MEDI

引用

页数：1

共 15 条

[1] 9-(Arenethenyl)purines as Dual Src/Abl Kinase Inhibitors Targeting the Inactive Conformation: Design, Synthesis, and Biological Evaluation
Huang, Wei-Sheng
Zhu, Xiaotian
Wang, Yihan
Azam, Mohammad
Wen, David
Sundaramoorthi, Raji
Thomas, R. Mathew
Liu, Shuangying
Banda, Geetha
Lentini, Scott P.
Das, Sasmita
Xu, Qihong
Keats, Jeff
Wang, Frank
Wardwell, Scott
Ning, Yaoyu
Snodgrass, Joseph T.
Broudy, Marc I.
Russian, Karin
Daley, George Q.
Iuliucci, John
Dalgarno, David C.
Clackson, Tim
Sawyer, Tomi K.
Shakespeare, William C.
JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (15) : 4743 - 4756
[2] Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors
Wang, Yihan
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Huang, Wei-Sheng
Sundaramoorthi, Raji
Lentini, Scott
Das, Sasmita
Liu, Shuangying
Banda, Geeta
Wen, David
Zhu, Xiaotian
Xu, Qihong
Keats, Jeffrey
Wang, Frank
Wardwell, Scott
Ning, Yaoyu
Snodgrass, Joseph T.
Broudy, Mark I.
Russian, Karin
Dalgarno, David
Clackson, Tim
Sawyer, Tomi K.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (17) : 4907 - 4912
[3] A Src-like inactive conformation in the Abl tyrosine kinase domain
Levinson, Nicholas M.
Kuchment, Olga
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Young, Matthew A.
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Karplus, Martin
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PLOS BIOLOGY, 2006, 4 (05) : 753 - 767
[4] Design of Potent and Selective Covalent Inhibitors of Bruton's Tyrosine Kinase Targeting an Inactive Conformation
Pulz, Robert
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ACS MEDICINAL CHEMISTRY LETTERS, 2019, 10 (10): : 1467 - 1472
[5] MEDI 105-Novel purine derivatives as potent dual Src/Abl tyrosine kinase inhibitors
Wang, Yihan
Shakespeare, William C.
Huang, Wei-sheng
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Banda, Geeta
Wen, David
Zhu, Xiaotian
Xu, Qihong
Keats, Jeff
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ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
[6] Activity of the potent dual Abl/Src tyrosine kinase inhibitor FB2 against Bcr-Abl positive cell lines in vitro and in vivo
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[7] Bone-targeted 2,6,9-trisubstituted purines: Novel inhibitors of Src tyrosine kinase for the treatment of bone diseases
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (18) : 3067 - 3070
[8] 3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases
Thaimattam, R
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BIOORGANIC & MEDICINAL CHEMISTRY, 2005, 13 (15) : 4704 - 4712
[9] Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (04) : 637 - 640
[10] Studies of N9-arenthenyl purines as novel DFG-in and DFG-out dual Src/Abl inhibitors using 3D-QSAR, docking and molecular dynamics simulations
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