An improved optimal image sampling schedule for multiple ROIS in dynamic SPECT

Optimal image sampling schedule (OISS) has been applied successfully to dynamic images for positron emission tomography (PET) with improved parameter estimation precision and significantly decreased image storage and processing requirements. OISS is usually based on one average curve for tissue, and the performance of OISS is still unclear when multiple regions of interest are considered in clinical diagnosis. An improved OISS is investigated with a modified objective function through a simulated study of the tracer 5-I-123-iodo-A-85380. The study shows that the improved OISS is at least as efficient in providing the accuracy and precision of parameter estimates as conventional and traditional OISS.