Oxoammonium salt-mediated oxidative nitriles synthesis from aldehydes with ammonium acetate

被引：11
|
作者：
Kim, Myeong Jin [1 ]
Mun, Junyoung [2 ]
Kim, Jinho [1 ]
机构：
[1] Incheon Natl Univ, Dept Chem, 119 Acad Ro, Incheon 22012, South Korea
[2] Incheon Natl Univ, Dept Energy & Chem Engn, 119 Acad Ro, Incheon 22012, South Korea
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 50期
关键词：
Oxoammonium salt; Nitriles; Ammonium acetate; Oxidation; Organic synthesis; AEROBIC ALCOHOL OXIDATION; AQUEOUS AMMONIA; HETEROGENEOUS CATALYST; NITROXYL RADICALS; MILD CONDITIONS; AMIDE SYNTHESIS; CONVERSION; EFFICIENT; ARYL; AMINES;
D O I：
10.1016/j.tetlet.2017.11.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and scalable route for the synthesis of nitriles was developed by oxoammonium salt (4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate) mediated oxidative conversion of aldehydes with NH4OAc. A variety of aliphatic aldehydes as well as benzaldehydes were converted into the corresponding nitriles in high yields. The nitroxyl radical which is the reduced species of the used oxoammonium salt was recovered by simple acid-base extraction for the recycling. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4695 / 4698
页数：4
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