Synthesis, characterization and antimicrobial activity of palladium(II) complexes with O,O' -dialkyl esters of ( S,S )-ethylenediamine- N,N' -di-(3,3?-1H-indol-3yl)-propionic acid

被引：4
|
作者：
Milic, Sandra S. Jovicic [1 ]
Jevtic, Verica V. [1 ]
Stojkovic, Danijela Lj. [1 ,2 ]
Petrovic, Dorde S. [1 ]
Avdovic, Edina H. [1 ,2 ]
Markovic, Zoran S. [2 ]
Radojevic, Ivana D. [3 ]
Comic, Ljiljana [3 ]
Mladenovic, Violeta S. [4 ]
机构：
[1] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanovica 12, Kragujevac 34000, Serbia
[2] Univ Kragujevac, Inst Informat Technol, Dept Sci, Kragujevac 34000, Serbia
[3] Univ Kragujevac, Fac Sci, Dept Biol & Ecol, Radoja Domanovica 12, Kragujevac 34000, Serbia
[4] Univ Kragujevac, Dept Internal Med, Fac Med Sci, Svetozara Markovica 69, Kragujevc 34000, Serbia
来源：
INORGANICA CHIMICA ACTA | 2020年 / 510卷
关键词：
STEREOSPECIFIC LIGANDS; ALKYL ESTERS; GROWTH;
D O I：
10.1016/j.ica.2020.119743
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of four new ligands of general formula R2-S,S-eddtrp·2HCl (L1–L4) and their palladium(II) complexes of general formula [PdCl2(R2-S,S-eddtrp)] (C1–C4) where R = ethyl, 1-propyl, 1-butyl and 1-pentyl; S,S-eddtrp·2HCl = ethylenediamine-N,N′-di-(3,3′-1H-indol-3yl)propionic acid dihydrochloride have been synthesized and characterized by elemental microanalysis, infrared, 1H and 13C NMR spectroscopy. The proposed structures of all compounds were examined by density functional theory (DFT). The ligands (L1–L4) and Pd(II) complexes (C1–C4) were screened for their antimicrobial activity against 19 microorganisms and minimum inhibitory concentrations (MIC) and minimum microbicidal concentration (MMC) were determinated. All tested ligands and complexes exhibited the highest antimicrobial activity on Escherichia coli ATCC 25922, being in range or higher than positive control, tetracycline. © 2020 Elsevier B.V.
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页数：6
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