Purpose. Our purpose was to study the possibility of using a novel method, namely, aerosol flow reactor method, for the preparation of drug-containing nanoparticles with varying amounts of drug and polymer. The physical properties of the prepared nanoparticles were analyzed. Methods. The nanoparticle size distributions were measured using differential mobility analyzer. The structure of the prepared nanoparticles was assessed by x-ray diffraction, differential scanning calorimetry, and electron microscopy. Drug release from the nanoparticles was analyzed. Results. The spherical particles produced showed a unimodal and lognormal size distribution, and the geometric number mean size of the nanoparticles could be varied between 90 and 200 nm. When the amount of drug in the polymeric matrix was small, the nanoparticles had a homogeneous, amorphous structure. Drug crystals were formed when the amount of drug was increased over the solubility limit of the drug into the polymer. The amounts of drug and polymer controlled the drug release from the nanoparticles. Conclusions. The aerosol flow reactor method was found to be able to produce homogeneous amorphous matrix-type nanoparticles that can directly be collected as dry powder.
机构:
Harvard Univ, Sch Med, MassGen Hosp Children, Dept Orthopaed Surg, Boston, MA USA
Harvard Univ, Sch Med, Pediat Orthopaed Lab Tissue Engn & Regenerat Med, Boston, MA USAHarvard Univ, Sch Med, MassGen Hosp Children, Dept Orthopaed Surg, Boston, MA USA
Grottkau, Brian E.
Cai, Xiaoxiao
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Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R ChinaHarvard Univ, Sch Med, MassGen Hosp Children, Dept Orthopaed Surg, Boston, MA USA
Cai, Xiaoxiao
Wang, Jing
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Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200092, Peoples R ChinaHarvard Univ, Sch Med, MassGen Hosp Children, Dept Orthopaed Surg, Boston, MA USA
Wang, Jing
Yang, Xingmei
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Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R ChinaHarvard Univ, Sch Med, MassGen Hosp Children, Dept Orthopaed Surg, Boston, MA USA
Yang, Xingmei
Lin, Yunfeng
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Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R ChinaHarvard Univ, Sch Med, MassGen Hosp Children, Dept Orthopaed Surg, Boston, MA USA
机构:
Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, Hong Kong, Peoples R China
Weng, Jingwen
Tong, Henry H. Y.
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Macao Polytech Inst, Sch Hlth Sci & Sports, Macau, Peoples R ChinaUniv Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, Hong Kong, Peoples R China
Tong, Henry H. Y.
Chow, Shing Fung
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Univ Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, Hong Kong, Peoples R ChinaUniv Hong Kong, Li Ka Shing Fac Med, Dept Pharmacol & Pharm, Pokfulam, Hong Kong, Peoples R China
机构:
Bishop Moore Coll, Res & Post Grad Dept Chem, Mavelikara, Kerala, India
Sree Narayana Coll, Dept Chem, Kollam, Kerala, IndiaBishop Moore Coll, Res & Post Grad Dept Chem, Mavelikara, Kerala, India
Thomas, Deepa
KurienThomas, K.
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Bishop Moore Coll, Res & Post Grad Dept Chem, Mavelikara, Kerala, IndiaBishop Moore Coll, Res & Post Grad Dept Chem, Mavelikara, Kerala, India
KurienThomas, K.
Latha, M. S.
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Sree Narayana Coll, Dept Chem, Chengannur, Kerala, India
Sree Narayana Coll, Dept Chem, Kollam, Kerala, IndiaBishop Moore Coll, Res & Post Grad Dept Chem, Mavelikara, Kerala, India